Tulassay Z, Flautner L, Fehérvári I, Sándor Z, Németh J
Semmelweis Orvostudományi Egyetem, Budapest.
Orv Hetil. 1992 Mar 29;133(13):777-80.
The prophylactic effect of perioperative use of somatostatin on postoperative increase of pancreatic digestive enzymes was investigated in this double blind, randomized study. Thirty three patients undergoing pancreatic surgery because of chronic pancreatitis were divided randomly into two groups. Fifteen patients received somatostatin- (dose 125 micrograms/hour), 18 placebo-infusion, pre- and postoperatively for a total time of 48 hours. The level of serum amylase, lipase, gammaGT, calcium, creatinine and blood glucose was determined every 12 hours. In the placebo group the serum lipase and amylase increased significantly (p less than 0.001), while the calcium decreased. In the somatostatin treated patients only the lipase level increased significantly (p less than 0.01), while the amylase and calcium showed no significant changes compared to their initial values. The postoperative increase in serum enzyme levels is interpreted as being an indicator of pancreatic injury. These results suggest that the perioperative use of somatostatin has beneficial effect for the prevention of pancreatic enzymes increases, associated with pancreatic surgery or its complications in patients with chronic pancreatitis.
在这项双盲、随机研究中，研究了围手术期使用生长抑素对术后胰腺消化酶升高的预防作用。33例因慢性胰腺炎接受胰腺手术的患者被随机分为两组。15例患者接受生长抑素（剂量为125微克/小时），18例接受安慰剂输注，术前和术后各持续48小时。每12小时测定血清淀粉酶、脂肪酶、γ-谷氨酰转移酶、钙、肌酐和血糖水平。在安慰剂组中，血清脂肪酶和淀粉酶显著升高（p<0.001），而钙降低。在接受生长抑素治疗的患者中，仅脂肪酶水平显著升高（p<0.01），而淀粉酶和钙与初始值相比无显著变化。血清酶水平的术后升高被解释为胰腺损伤的指标。这些结果表明，围手术期使用生长抑素对预防慢性胰腺炎患者胰腺手术或其并发症相关的胰腺酶升高具有有益作用。
