Klempa I, Schwedes U, Usadel K H
Chirurg. 1979 Jul;50(7):427-31.
Somatostatin was prophylactically administered to 10 patients who had surgery for pancreatic diseases. The postoperative course uncomplicated with no increase in serum amylase levels. Bile induced acute pancreatitis in six beagles was prophylactically treated with somatostatin. The results demonstrate that SRIF not only inhibits basal but also pancreatic-induced blood amylase and enzyme activities in the dog. SRIF-treated animals were in good general condition compared with untreated controls, macroscopic and histologic aspects of the pancreas were significantly improved.
对10例接受胰腺疾病手术的患者预防性给予生长抑素。术后病程顺利，血清淀粉酶水平未升高。对6只比格犬胆汁诱导的急性胰腺炎预防性给予生长抑素治疗。结果表明，生长抑素释放抑制因子不仅抑制基础状态下的，而且抑制犬胰腺诱导的血液淀粉酶和酶活性。与未治疗的对照组相比，接受生长抑素释放抑制因子治疗的动物总体状况良好，胰腺的大体和组织学方面均有显著改善。
