Federal University of São Paulo, São Paulo, Brazil.
J Am Acad Dermatol. 2013 Dec;69(6 Suppl 1):S36-41. doi: 10.1016/j.jaad.2013.04.042.
Rosacea is a prevalent disorder that may be disfiguring and cause significant ocular morbidity, if not diagnosed and managed appropriately. Ocular rosacea, in particular, is often left undiagnosed as no specific test is available to confirm the diagnosis. Accurate diagnosis is further complicated because symptoms of ocular rosacea are not always specific to the disorder alone. Other ophthalmic disorders may present with similar findings. Further challenges exist because the severity of ocular symptoms is often not related to the severity of cutaneous findings in rosacea. Isolating a disease marker may facilitate earlier diagnosis and treatment, and could also contribute to better understanding of disease pathogenesis. The glycomics of tear fluid and saliva in patients with rosacea shows promise as an initial step in the search for a biomarker specific to the disease. We have previously found potentially important disease biomarkers in roseatic tear and saliva samples. Further investigation should prove important in the early stages of developing a set of markers for accurate disease identification.
酒渣鼻是一种常见的疾病，如果不能得到正确的诊断和治疗，可能会导致毁容和严重的眼部疾病。特别是眼部酒渣鼻，由于没有特定的检查来确认诊断，因此常常被漏诊。准确的诊断变得更加复杂，因为眼部酒渣鼻的症状并不总是与该疾病单独相关。其他眼部疾病也可能出现类似的表现。进一步的挑战在于，眼部症状的严重程度通常与酒渣鼻的皮肤表现严重程度无关。分离疾病标志物可能有助于更早地诊断和治疗，也有助于更好地了解疾病的发病机制。在寻找特定于疾病的生物标志物方面，泪液和唾液中的糖组学显示出了希望。我们之前在玫瑰痤疮的泪液和唾液样本中发现了潜在的重要疾病生物标志物。进一步的研究对于开发一套用于准确识别疾病的标志物的早期阶段应该是重要的。
