Xue Qiao, Pan Jian Peng, Qian Da, Ji Jie, Fei Lai Yi, Yao Sheng, Tan Xing, Fan Wen Ge
Department of Dermatology, Changshu No. 1 People's Hospital, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu, 215500, People's Republic of China.
Department of Hand Surgery, Changshu No. 2 People's Hospital, The Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, 215500, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jan 20;18:191-200. doi: 10.2147/CCID.S495773. eCollection 2025.
Rosacea is a common chronic inflammatory disorder primarily affecting the face. While inflammatory factors are known to play a pivotal role in its pathogenesis, their causal relationship with rosacea remains unclear. This study employed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal links between systemic inflammatory regulators and rosacea.
Data on 41 cytokines and growth factors were analyzed from a genome-wide association study (GWAS) meta-analysis involving 8293 individuals and genetic data from the FinnGen database, comprising 1195 rosacea cases and 211,139 controls. The principal inverse variance weighting (IVW) method was used to assess causal relationships, with sensitivity analyses, including heterogeneity and horizontal pleiotropy assessments, conducted to ensure result robustness.
MR analysis revealed that decreased expression of Stem Cell Factor (SCF), Macrophage Inflammatory Protein-1β (MIP-1β), and Monocyte Chemotactic Protein-1 (MCP-1) was associated with increased rosacea risk (OR = 1.54, 95% CI = 1.05-2.26, p = 0.026). Conversely, elevated expression levels of Stromal Cell-Derived Factor-1α (SDF-1α) and Hepatocyte Growth Factor (HGF) were linked to higher rosacea risk (OR = 1.61, 95% CI = 1.12-2.31, p = 0.009). Reverse MR analyses showed no significant impact of rosacea on systemic inflammatory regulator expression.
This study identified five inflammatory factors-SCF, SDF-1α, MCP-1, HGF, and MIP-1β-as having causal relationships with rosacea pathogenesis. Further research is required to elucidate their mechanistic roles in disease development.
酒渣鼻是一种常见的慢性炎症性疾病，主要影响面部。虽然已知炎症因子在其发病机制中起关键作用，但其与酒渣鼻的因果关系仍不清楚。本研究采用两样本双向孟德尔随机化（MR）分析来研究全身炎症调节因子与酒渣鼻之间的因果联系。
对来自一项涉及8293名个体的全基因组关联研究（GWAS）荟萃分析中的41种细胞因子和生长因子数据以及来自芬兰基因数据库的遗传数据进行分析，该数据库包含1195例酒渣鼻病例和211,139名对照。采用主要的逆方差加权（IVW）方法评估因果关系，并进行敏感性分析，包括异质性和水平多效性评估，以确保结果的稳健性。
MR分析显示，干细胞因子（SCF）、巨噬细胞炎性蛋白-1β（MIP-1β）和单核细胞趋化蛋白-1（MCP-1）表达降低与酒渣鼻风险增加相关（OR = 1.54，95% CI = 1.05 - 2.26，p = 0.026）。相反，基质细胞衍生因子-1α（SDF-1α）和肝细胞生长因子（HGF）表达水平升高与酒渣鼻风险较高相关（OR = 1.61，95% CI = 1.12 - 2.31，p = 0.009）。反向MR分析显示酒渣鼻对全身炎症调节因子表达无显著影响。
本研究确定了五种炎症因子——SCF、SDF-1α、MCP-1、HGF和MIP-1β——与酒渣鼻发病机制存在因果关系。需要进一步研究以阐明它们在疾病发展中的机制作用。
