AGE-RAGE 通路及其与慢性肾脏病患者心血管疾病的关系。

The AGE-RAGE pathway and its relation to cardiovascular disease in patients with chronic kidney disease.

机构信息

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Arch Med Res. 2013 Nov;44(8):601-10. doi: 10.1016/j.arcmed.2013.11.002. Epub 2013 Nov 11.

DOI:10.1016/j.arcmed.2013.11.002

PMID:24231387

Abstract

Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-products (AGE)-receptor for AGE (RAGE) pathway is likely a major contributor in patients with CKD. This review describes briefly some of the components of this pathway, highlighting especially differences between circulating AGE and tissue AGE and how activation of the AGE-RAGE pathway may promote CVD in CKD.

摘要

慢性肾脏病（CKD）无疑会增加心血管疾病（CVD）的风险，导致高发病率和死亡率；然而，其根本原因尚未完全明确。在 CVD 的病理生理学机制中，晚期糖基化终产物（AGE）-AGE 受体（RAGE）途径的慢性过度刺激可能是 CKD 患者的一个主要致病因素。本文简要描述了该途径的一些组成部分，特别强调了循环 AGE 与组织 AGE 之间的差异，以及 AGE-RAGE 途径的激活如何促进 CKD 中的 CVD。