Joseph Nidhin, Zhang-James Yanli, Perl Andras, Faraone Stephen V
State University of New York Upstate Medical University, Syracuse, USA.
State University of New York Upstate Medical University, Syracuse, USA
J Atten Disord. 2015 Nov;19(11):915-24. doi: 10.1177/1087054713510354. Epub 2013 Nov 14.
To clarify the role of oxidative stress and antioxidant activity in ADHD.
We examined the association of ADHD and oxidative stress by applying random effects meta-analysis to studies of oxidative stress and antioxidant status in medication naive patients with ADHD and controls.
Six studies of a total of 231 ADHD patients and 207 controls met our selection criteria. The association between ADHD and antioxidant status was not significant. We found a significant association between ADHD and oxidative stress that could not be accounted for by publication bias. The significant association lost significance after correcting for intrastudy clustering. No one observation accounted for the positive result.
These results are preliminary given the small number of studies. They suggest that patients with ADHD have normal levels of antioxidant production, but that their response to oxidative stress is insufficient, leading to oxidative damage.
阐明氧化应激和抗氧化活性在注意力缺陷多动障碍（ADHD）中的作用。
我们通过对未服用药物的ADHD患者和对照组的氧化应激及抗氧化状态研究进行随机效应荟萃分析，来检验ADHD与氧化应激之间的关联。
共有231例ADHD患者和207例对照组参与的6项研究符合我们的入选标准。ADHD与抗氧化状态之间的关联不显著。我们发现ADHD与氧化应激之间存在显著关联，且这种关联不能用发表偏倚来解释。在校正研究内聚类后，这种显著关联失去了显著性。没有一项观察结果能解释这一阳性结果。
鉴于研究数量较少，这些结果是初步的。它们表明ADHD患者的抗氧化物质产生水平正常，但其对氧化应激的反应不足，导致氧化损伤。
