Bentzinger C Florian, Wang Yu Xin, Dumont Nicolas A, Rudnicki Michael A
Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
EMBO Rep. 2013 Dec;14(12):1062-72. doi: 10.1038/embor.2013.182. Epub 2013 Nov 15.
Satellite cells, the quintessential skeletal muscle stem cells, reside in a specialized local environment whose anatomy changes dynamically during tissue regeneration. The plasticity of this niche is attributable to regulation by the stem cells themselves and to a multitude of functionally diverse cell types. In particular, immune cells, fibrogenic cells, vessel-associated cells and committed and differentiated cells of the myogenic lineage have emerged as important constituents of the satellite cell niche. Here, we discuss the cellular dynamics during muscle regeneration and how disease can lead to perturbation of these mechanisms. To define the role of cellular components in the muscle stem cell niche is imperative for the development of cell-based therapies, as well as to better understand the pathobiology of degenerative conditions of the skeletal musculature.
卫星细胞是典型的骨骼肌干细胞，存在于一个特殊的局部环境中，其解剖结构在组织再生过程中会动态变化。这种生态位的可塑性归因于干细胞自身的调控以及多种功能各异的细胞类型。特别是，免疫细胞、成纤维细胞、血管相关细胞以及肌源性谱系的定向分化细胞已成为卫星细胞生态位的重要组成部分。在此，我们讨论肌肉再生过程中的细胞动态变化，以及疾病如何导致这些机制的紊乱。明确细胞成分在肌肉干细胞生态位中的作用对于基于细胞的治疗方法的开发至关重要，同时也有助于更好地理解骨骼肌退化性疾病的病理生物学。
