Warren C P, Holford-Strevens V
Environ Health Perspect. 1986 Apr;66:55-9. doi: 10.1289/ehp.866655.
The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic histamine release from peritoneal cells but not from purified mast cells. This reaction was dependent on the presence of phosphatidyl serine. The agent did not appear to be a lectin because histamine release was not enhanced by passive sensitization of mast cells with IgE. The activity occurred only over a narrow range of concentrations of the extract of wheat. The cause was unclear.
研究了谷物粉尘和小麦提取物诱导大鼠腹腔细胞释放组胺的能力。发现一些内毒素含量高的谷物粉尘可产生细胞毒性组胺释放。内毒素释放量低的小麦粉尘提取物可使腹腔细胞而非纯化的肥大细胞产生非细胞毒性组胺释放。该反应依赖于磷脂酰丝氨酸的存在。该物质似乎不是凝集素,因为用IgE对肥大细胞进行被动致敏不会增强组胺释放。该活性仅在小麦提取物的狭窄浓度范围内出现。原因尚不清楚。