Cotton D J, Graham B L, Li K Y, Froh F, Barnett G D, Dosman J A
J Occup Med. 1983 Feb;25(2):131-41.
In four groups of individually-matched subjects (nonsmoking grain workers, smoking grain workers, nonsmoking community controls, and smoking community controls) we measured pulmonary function variables from the spirogram, from the maximal expiratory flow-volume curve breathing air and helium, and from the single breath nitrogen test as well as symptom prevalences from a questionnaire in order to assess the relative effects of smoking and occupational exposure to grain dust in Saskatchewan country grain elevators. There were similar increased prevalences of respiratory symptoms and reductions in pulmonary function associated with either grain dust exposure or smoking, but the effects of smoking were slightly more pronounced. The combined effects of grain dust and smoking on lung function appeared to be additive except in the least exposed workers (five years or less) where a synergistic effect was observed in tests of peripheral airways dysfunction.
在四组个体匹配的受试者中（非吸烟谷物工人、吸烟谷物工人、非吸烟社区对照者和吸烟社区对照者），我们测量了来自肺活量计的肺功能变量、呼吸空气和氦气时的最大呼气流量-容积曲线以及单次呼吸氮试验，还通过问卷调查了症状患病率，以评估吸烟和萨斯喀彻温省乡村谷物升降机中职业性接触谷物粉尘的相对影响。与谷物粉尘暴露或吸烟相关的呼吸道症状患病率均有类似增加，肺功能也均有下降，但吸烟的影响略为明显。谷物粉尘和吸烟对肺功能的综合影响似乎是相加的，不过在暴露最少的工人（五年或更短时间）中，在外周气道功能障碍测试中观察到了协同作用。
