Servadio C, Abramovici A, Sandbank U, Savion M, Rosen M
Eur Urol. 1986;12(3):195-200. doi: 10.1159/000472615.
Typical lesions of benign prostatic hyperplasia (BPH) were induced experimentally in the ventral prostate of adolescent (6 week old) male rats by citral, a nonsteroidal compound. Incipient BPH changes were already observed in the acinar glands 10 days after citral administration. A longer period of treatment (1 month) significantly enhanced epithelial hyperplasia, whereas the stromal elements were less reactive. Characteristic BPH lesions involving both prostatic compartments were found after 3 months of treatment. Castration prior to citral administration prevented such BPH changes; however, citral did not prevent the involutive lesions of castration. The mechanism of action of citral is yet unknown, various possibilities concerning the induction of BPH in rats are presented and discussed. The potential advantage of this model, especially as BPH is not necessarily linked to age or exogenous hormones, may offer new alternative pathways for understanding the complexity of BPH pathogenesis in animals and perhaps even in man.
通过非甾体化合物柠檬醛在青春期（6周龄）雄性大鼠的腹侧前列腺中实验性诱导出良性前列腺增生（BPH）的典型病变。在给予柠檬醛10天后，腺泡中已观察到早期BPH变化。较长时间的治疗（1个月）显著增强了上皮增生，而基质成分的反应性较低。治疗3个月后发现了涉及前列腺两个部分的典型BPH病变。在给予柠檬醛之前进行去势可预防此类BPH变化；然而，柠檬醛并不能预防去势后的退化性病变。柠檬醛的作用机制尚不清楚，文中提出并讨论了关于在大鼠中诱导BPH的各种可能性。该模型的潜在优势，特别是由于BPH不一定与年龄或外源性激素相关，可能为理解动物甚至人类BPH发病机制的复杂性提供新的替代途径。
