过氧化物可使血红蛋白释放出芬顿反应和脂质过氧化反应的铁促发剂。
Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides.
作者信息
Gutteridge J M
出版信息
FEBS Lett. 1986 Jun 9;201(2):291-5. doi: 10.1016/0014-5793(86)80626-3.
PMID:2423372
Abstract
Hydrogen peroxide and organic hydroperoxides react with haemoglobin to release iron which can be complexed to apotransferrin, bleomycin and desferrioxamine. This released iron promotes deoxyribose degradation by a Fenton reaction, DNA degradation in the presence of bleomycin and stimulates lipid peroxidation. It is likely that iron released from haemoglobin is the true generator of hydroxyl radicals in the Fenton reaction.
摘要
过氧化氢和有机氢过氧化物与血红蛋白反应释放出铁，该铁可与脱铁转铁蛋白、博来霉素和去铁胺络合。这种释放出的铁通过芬顿反应促进脱氧核糖降解、在博来霉素存在的情况下促进DNA降解并刺激脂质过氧化。很可能从血红蛋白释放出的铁是芬顿反应中真正的羟基自由基产生者。
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