芦荟凝胶作为口腔黏膜下纤维性变辅助治疗的疗效。
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis.
机构信息
Senior Lecturer, Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):717-24. doi: 10.1016/j.oooo.2013.08.003.
OBJECTIVE
Definitive therapy is not defined for the management of oral submucous fibrosis (OSMF). This study evaluated the efficacy of aloe vera gel as an adjuvant treatment of OSMF.
STUDY DESIGN
A double-blind, placebo-controlled, parallel-group randomized controlled trial was conducted on 60 subjects with OSMF divided into medicinal treatment (submucosal injection of hyaluronidase and dexamethasone, n = 30) and surgical treatment (n = 30) categories. Each category was randomly divided into groups A (with aloe vera, n = 15 per category) and B (without aloe vera, n = 15 per category). Follow-up assessment for various symptoms was performed, and results were analyzed using paired and unpaired Student t tests.
RESULTS
The group receiving aloe vera had a significant improvement in most symptoms of OSMF (P < .01) compared with the non-aloe vera group, in both the medicinal and surgical categories.
CONCLUSIONS
Aloe vera gel was effective as an adjuvant in treatment of OSMF.
目的
口腔黏膜下纤维化（OSMF）的治疗方法尚未明确。本研究评估了芦荟凝胶作为 OSMF 辅助治疗的疗效。
研究设计
对 60 例 OSMF 患者进行了一项双盲、安慰剂对照、平行组随机对照试验，将患者分为药物治疗（黏膜下注射透明质酸酶和地塞米松，n = 30）和手术治疗（n = 30）两类。每类再随机分为 A 组（含芦荟，n = 15）和 B 组（不含芦荟，n = 15）。对各种症状进行随访评估，并采用配对和非配对学生 t 检验分析结果。
结果
与非芦荟组相比，药物和手术治疗组中接受芦荟治疗的患者 OSMF 的大多数症状均显著改善（P <.01）。
结论
芦荟凝胶作为 OSMF 的辅助治疗有效。
Zotero 插件