Senior Lecturer, Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):717-24. doi: 10.1016/j.oooo.2013.08.003.
Definitive therapy is not defined for the management of oral submucous fibrosis (OSMF). This study evaluated the efficacy of aloe vera gel as an adjuvant treatment of OSMF.
A double-blind, placebo-controlled, parallel-group randomized controlled trial was conducted on 60 subjects with OSMF divided into medicinal treatment (submucosal injection of hyaluronidase and dexamethasone, n = 30) and surgical treatment (n = 30) categories. Each category was randomly divided into groups A (with aloe vera, n = 15 per category) and B (without aloe vera, n = 15 per category). Follow-up assessment for various symptoms was performed, and results were analyzed using paired and unpaired Student t tests.
The group receiving aloe vera had a significant improvement in most symptoms of OSMF (P < .01) compared with the non-aloe vera group, in both the medicinal and surgical categories.
Aloe vera gel was effective as an adjuvant in treatment of OSMF.
口腔黏膜下纤维化（OSMF）的治疗方法尚未明确。本研究评估了芦荟凝胶作为 OSMF 辅助治疗的疗效。
对 60 例 OSMF 患者进行了一项双盲、安慰剂对照、平行组随机对照试验，将患者分为药物治疗（黏膜下注射透明质酸酶和地塞米松，n = 30）和手术治疗（n = 30）两类。每类再随机分为 A 组（含芦荟，n = 15）和 B 组（不含芦荟，n = 15）。对各种症状进行随访评估，并采用配对和非配对学生 t 检验分析结果。
与非芦荟组相比，药物和手术治疗组中接受芦荟治疗的患者 OSMF 的大多数症状均显著改善（P <.01）。
芦荟凝胶作为 OSMF 的辅助治疗有效。
