Department of Laboratory Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 136-705, South Korea.
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 86 Asanbyungwon-gil, Songpa-gu, Seoul 138-736, South Korea.
Leuk Res. 2014 Jan;38(1):65-70. doi: 10.1016/j.leukres.2013.10.016. Epub 2013 Oct 28.
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p=0.01) and overall survival (p=0.04) and patients with low VLA-4 expression had shorter disease-free survival (p=0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.
关于 CXCR4 和 VLA-4 在 ALL 中的预后意义的数据有限。特别是，在成人和儿童 ALL 患者的诊断时均未评估 VLA-4。我们前瞻性地通过流式细胞术分析了 54 例新诊断为 ALL 的患者（VLA-4 为 29 例成人和 25 例儿童，CXCR4 为 22 例成人和 24 例儿童）的 VLA-4 和 CXCR4 表达。成人 ALL 患者与儿童 ALL 患者的 VLA-4 和 CXCR4 表达水平无差异。高 CXCR4 和低 VLA-4 表达均与成人的预后不良相关；高 CXCR4 表达的患者无病生存期较短（p=0.01）和总生存期较短（p=0.04），低 VLA-4 表达的患者无病生存期较短（p=0.02）。CXCR4 和 VLA-4 的表达水平不能预测儿童患者的预后。分析成人 ALL 患者诊断时的 CXCR4 和 VLA-4 表达水平可以为患者预后提供有用的信息。
