Department of Psychiatry, Virginia Commonwealth University, United States.
Schizophr Res. 2013 Dec;151(1-3):226-8. doi: 10.1016/j.schres.2013.10.016. Epub 2013 Nov 12.
Epidemiological studies suggest that height and schizophrenia risk are inversely correlated. These findings might arise because i) height and schizophrenia share genetic variants and ii) the effects of these shared variants are in opposite direction for the two traits. We use genome wide association data to empirically evaluate these hypotheses. We find that variants which impact on height and risk for schizophrenia are distributed across several genomic regions and the directions of effect vary, some consistent and others inconsistent with the direction expected from the phenotypic data. Moreover, signals that were in and not in accord with the phenotypic data aggregated in distinct biological pathways.
流行病学研究表明，身高与精神分裂症风险呈负相关。这些发现可能是因为 i）身高和精神分裂症共享遗传变异，以及 ii）这些共享变异对两种特征的影响方向相反。我们使用全基因组关联数据来实证评估这些假设。我们发现，影响身高和精神分裂症风险的变异分布在几个基因组区域，作用方向也各不相同，有些与表型数据预期的方向一致，有些则不一致。此外，与表型数据一致和不一致的信号在不同的生物学途径中聚集。
