Górny M K, Wróblewska Z, Pleasure D, Miller S L, Wajgt A, Koprowski H
Acta Neurol Scand. 1983 Jun;67(6):338-47. doi: 10.1111/j.1600-0404.1983.tb03151.x.
Cerebrospinal fluid (CSF) from 18 multiple sclerosis (MS) patients, 13 subacute sclerosing panencephalitis (SSPE) patients, 22 other neurological disease (OND) patients, and 7 neurotic patients as controls were tested in an 125I-labeled anti-human F(ab')2 binding assay for the presence of antibodies to normal human brain cells from tissue culture, human fibroblasts, plasma membranes of MS and normal human brain, myelin basic protein (MBP) and bovine oligodendrocytes. Antibodies to MBP and to oligodendrocytes were found in the CSF of MS, SSPE and OND patients. Absorption of CSF with bovine CNS myelin significantly diminished binding activity to oligodendrocytes. Antibodies in the CSF against MBP and oligodendrocytes, on which some myelin determinants are expressed, seem to be a common feature of diseases in which demyelination is a component.
在一项¹²⁵I标记的抗人F(ab')₂结合试验中，检测了18例多发性硬化症（MS）患者、13例亚急性硬化性全脑炎（SSPE）患者、22例其他神经系统疾病（OND）患者以及7例作为对照的神经症患者的脑脊液（CSF），以检测其中是否存在针对来自组织培养的正常人脑细胞、人成纤维细胞、MS和正常人脑的质膜、髓鞘碱性蛋白（MBP）以及牛少突胶质细胞的抗体。在MS、SSPE和OND患者的脑脊液中发现了针对MBP和少突胶质细胞的抗体。用牛中枢神经系统髓鞘吸收脑脊液可显著降低与少突胶质细胞的结合活性。脑脊液中针对MBP和少突胶质细胞的抗体（少突胶质细胞表达一些髓鞘决定簇）似乎是脱髓鞘为其中一个组成部分的疾病的共同特征。
