Kattel Krishna, Park Ja Young, Xu Wenlong, Bony Badrul Alam, Heo Woo Cheol, Tegafaw Tirusew, Kim Cho Rong, Ahmad M Wasi, Jin Seonguk, Baeck Jong Su, Chang Yongmin, Kim Tae Jeong, Bae Ji Eun, Chae Kwon Seok, Jeong Ji Yun, Lee Gang Ho
Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 702-701, South Korea.
J Nanosci Nanotechnol. 2013 Nov;13(11):7214-9. doi: 10.1166/jnn.2013.8081.
The water-soluble and biocompatible D-glucuronic acid coated Eu(OH)3 nanorods (average thickness x average length = 9.0 x 118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at approximately 600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 microM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be approximately 0.1 mM. Therefore, D-glucuronic acid coated Eu(OH)3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of approximately 1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.
通过一锅合成法制备了水溶性且具有生物相容性的D-葡萄糖醛酸包覆的Eu(OH)₃纳米棒（平均厚度×平均长度 = 9.0×118.3 nm）。D-葡萄糖醛酸包覆的Eu(OH)₃纳米棒在约600 nm处显示出强荧光，发射带宽较窄。使用DU145细胞进行的细胞毒性测试表明，D-葡萄糖醛酸包覆的Eu(OH)₃纳米棒在浓度高达100 microM时无毒，这使其成为荧光成像等生物医学应用的有前景候选物。传统共聚焦成像所需的最低Eu浓度估计约为0.1 mM。因此，D-葡萄糖醛酸包覆的Eu(OH)₃纳米棒可应用于荧光成像。然而，在室温及5特斯拉的外加磁场下观察到约1.2 emu/g的非常小的磁化强度。结果，估计r1和r2水质子弛豫率非常小，这意味着表面包覆的Eu(OH)₃纳米棒不足以用作MRI造影剂。
