Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, Canada.
Environ Int. 2014 Feb;63:26-34. doi: 10.1016/j.envint.2013.10.012. Epub 2013 Nov 16.
Pooling of surplus serum from individual samples, collected between 2007 and 2009 during Cycle 1 of the Canadian Health Measures Survey (CHMS), was performed to develop a national baseline estimate of brominated flame retardants in Canadians. Serum samples were categorized by sex and distributed by five age groups ranging from 6 to 79years. Nearly 5000 (4583) serum samples were used to form 59 composite pools. Serum pools were created to ensure a high detection frequency of these analytes in serum because low volume samples had previously resulted in non-detectable concentrations. The analytes of interest in these serum pools included 23 polybrominated diphenyl ethers (PBDEs) and three hexabromocyclododecane (HBCD) isomers (α-, β- and γ-HBCD). PBDEs were observed in all samples tested and total PBDE concentrations ranged from 27ngg(-1) lipid to 130ngg(-1) lipid (geometric mean [GM] 46ngg(-1) lipid). ∑PBDE concentrations were significantly elevated in samples representing the 6-11year old age group (GM 65ngg(-1) lipid) relative to ages above 40years, although no difference in concentration was observed between the sexes. PBDE concentrations in Canadian sera from the general population were higher than reported in Europe and Asia, but a little lower than observed in the US. PBDE 47 was the greatest contributor to ∑PBDE concentrations and the GM concentration for this congener was 22ngg(-1) lipid. The other dominant contributors to ∑PBDE concentrations were in descending order: 153 [GM 9.4ngg(-1) lipid]>99 [GM 4.6ngg(-1) lipid]≅100 [GM 4.1ngg(-1) lipid]>209 [GM 1.1ngg(-1) lipid] and 183 [GM 0.42ngg(-1) lipid]. ∑HBCD was detected in all samples analysed, although most samples were observed at concentrations <1ngg(-1) lipid, similar to global concentrations. α-HBCD was the dominant contributor to ∑HBCD concentrations in Canadians although β- and γ-HBCD were detected in 23% and 35% of the samples, respectively. No differences in ∑HBCD concentration were associated with age or sex. This dataset represents the first national data describing HBCD isomers and some PBDEs (e.g., 183, 209) in Canadians.
将 2007 年至 2009 年期间加拿大健康衡量调查（CHMS）第 1 周期采集的个体样本的多余血清进行汇集，以制定加拿大溴化阻燃剂的国家基线估计值。血清样本按性别分类，并按 6 至 79 岁的五个年龄组分布。近 5000（4583）个血清样本用于形成 59 个复合池。创建血清池是为了确保这些分析物在血清中的高检测频率，因为以前小体积样本导致无法检测到浓度。这些血清池中感兴趣的分析物包括 23 种多溴二苯醚（PBDEs）和三种六溴环十二烷（HBCD）异构体（α-、β-和 γ-HBCD）。所有测试样本均观察到 PBDEs，总 PBDE 浓度范围为 27ngg(-1) 脂质至 130ngg(-1) 脂质（几何平均值 [GM] 46ngg(-1) 脂质）。代表 6-11 岁年龄组的样本中，∑PBDE 浓度显著升高（GM 65ngg(-1) 脂质），与 40 岁以上年龄组相比，尽管男女之间未观察到浓度差异。加拿大普通人群血清中的 PBDE 浓度高于欧洲和亚洲的报告，但略低于美国的观察结果。PBDE 47 是∑PBDE 浓度的最大贡献者，该同系物的 GM 浓度为 22ngg(-1) 脂质。∑PBDE 浓度的其他主要贡献者按降序排列：153[GM 9.4ngg(-1) 脂质]>99[GM 4.6ngg(-1) 脂质]≅100[GM 4.1ngg(-1) 脂质]>209[GM 1.1ngg(-1) 脂质]和 183[GM 0.42ngg(-1) 脂质]。所有分析的样本中均检测到∑HBCD，但大多数样本的浓度<1ngg(-1) 脂质，与全球浓度相似。α-HBCD 是加拿大∑HBCD 浓度的主要贡献者，尽管β-和 γ-HBCD 分别在 23%和 35%的样本中检测到。∑HBCD 浓度与年龄或性别无关。该数据集代表加拿大首次描述 HBCD 异构体和一些 PBDE（例如 183、209）的全国性数据。
