Manne Sharon, Kashy Deborah, Albrecht Terrance, Wong Yu-Ning, Flamm Anne Lederman, Benson Al B, Miller Suzanne M, Fleisher Linda, Buzaglo Joanne, Roach Nancy, Katz Michael, Ross Eric, Collins Michael, Poole David, Raivitch Stephanie, Miller Dawn M, Kinzy Tyler G, Liu Tasnuva, Meropol Neal J
Cancer Institute of New Jersey, New Brunswick, NJ, USA (SM).
Department of Psychology, Michigan State University, East Lansing, MI, USA (DK)
Med Decis Making. 2014 May;34(4):454-63. doi: 10.1177/0272989X13511704. Epub 2013 Nov 18.
This study used the Ottawa Decision Support Framework to evaluate a model examining associations between clinical trial knowledge, attitudinal barriers to participating in clinical trials, clinical trial self-efficacy, and clinical trial preparedness among 1256 cancer patients seen for their first outpatient consultation at a cancer center. As an exploratory aim, moderator effects for gender, race/ethnicity, education, and metastatic status on associations in the model were evaluated.
. Patients completed measures of cancer clinical trial knowledge, attitudinal barriers, self-efficacy, and preparedness. Structural equation modeling (SEM) was conducted to evaluate whether self-efficacy mediated the association between knowledge and barriers with preparedness.
. The SEM explained 26% of the variance in cancer clinical trial preparedness. Self-efficacy mediated the associations between attitudinal barriers and preparedness, but self-efficacy did not mediate the knowledge-preparedness relationship.
. Findings partially support the Ottawa Decision Support Framework and suggest that assessing patients' level of self-efficacy may be just as important as evaluating their knowledge and attitudes about cancer clinical trials.
本研究采用渥太华决策支持框架，对一个模型进行评估，该模型考察了1256名在癌症中心首次接受门诊咨询的癌症患者的临床试验知识、参与临床试验的态度障碍、临床试验自我效能感和临床试验准备情况之间的关联。作为一个探索性目标，评估了性别、种族/民族、教育程度和转移状态对模型中各关联的调节作用。
患者完成了癌症临床试验知识、态度障碍、自我效能感和准备情况的测量。进行了结构方程建模（SEM），以评估自我效能感是否介导了知识与障碍和准备情况之间的关联。
结构方程模型解释了癌症临床试验准备情况中26%的方差变异。自我效能感介导了态度障碍与准备情况之间的关联，但自我效能感并未介导知识与准备情况之间的关系。
研究结果部分支持渥太华决策支持框架，并表明评估患者的自我效能感水平可能与评估他们对癌症临床试验的知识和态度同样重要。
