比较 MDRD 研究和 CKD-EPI 方程在韩国一般人群中肾小球滤过率估计中的应用：第五次韩国国家健康和营养检查调查（KNHANES V-1），2010 年。
Comparison of the MDRD study and CKD-EPI equations for the estimation of the glomerular filtration rate in the Korean general population: the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1), 2010.
机构信息
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
出版信息
Kidney Blood Press Res. 2013;37(4-5):443-50. doi: 10.1159/000355724. Epub 2013 Oct 15.
BACKGROUND
We compared the accuracy of the Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in Korean patients and evaluated the difference in CKD prevalence determined using the two equations in the Korean general population.
METHODS
The accuracy of the two equations was evaluated in 607 patients who underwent a chromium-51-ethylenediaminetetraacetic acid GFR measurement. Additionally, we compared the difference in CKD prevalence determined by the two equations among 5,822 participants in the fifth Korea National Health and Nutrition Examination Survey, 2010.
RESULTS
Among the 607 subjects, the median bias of the CKD-EPI equation was significantly lower than that of the MDRD study equation (0.9 vs. 2.2, p=0.020). The accuracy of the two equations was not significantly different in patients with mGFR <60 mL/min/1.73m(2); however, the accuracy of the CKD-EPI equation was significantly higher than that of the MDRD study equation in patients with GFR ≥60 mL/min/1.73m(2). The prevalences of the CKD stages 1, 2 and 3 in the Korean general population were 47.56, 49.23, and 3.07%, respectively, for the MDRD study equation; and were 68.48, 28.89, and 2.49%, respectively, for the CKD-EPI equation.
CONCLUSIONS
These data suggest that the CKD-EPI equation might be more useful in clinical practice than the MDRD study equation in Koreans.
背景
我们比较了 Modification of Diet in Renal Disease（MDRD）研究和 Chronic Kidney Disease Epidemiology Collaboration（CKD-EPI）公式在韩国患者中的准确性，并评估了这两种公式在韩国普通人群中确定的慢性肾脏病（CKD）患病率的差异。
方法
我们评估了 607 例接受铬-51-乙二胺四乙酸 GFR 测量的患者的这两种方程的准确性。此外，我们比较了 2010 年第五次韩国国家健康和营养检查调查中 5822 名参与者中，这两种方程确定的 CKD 患病率的差异。
结果
在 607 例受试者中，CKD-EPI 方程的中位偏差明显低于 MDRD 研究方程（0.9 对 2.2，p=0.020）。在 mGFR<60 mL/min/1.73m(2)的患者中，两种方程的准确性没有显著差异；然而，在 GFR≥60 mL/min/1.73m(2)的患者中，CKD-EPI 方程的准确性明显高于 MDRD 研究方程。在韩国普通人群中，CKD 各期 1、2 和 3 的患病率分别为 MDRD 研究方程的 47.56%、49.23%和 3.07%；CKD-EPI 方程分别为 68.48%、28.89%和 2.49%。
结论
这些数据表明，在韩国人群中，CKD-EPI 方程在临床实践中可能比 MDRD 研究方程更有用。
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