Abenoza P, Sibley R K
Hum Pathol. 1986 Jul;17(7):744-7. doi: 10.1016/s0046-8177(86)80185-x.
Fourteen chordomas, five myxoid chondrosarcomas, and 15 chondroid tumors (four mesenchymal and 11 conventional chondrosarcomas) were stained for cytokeratin, S-100 protein, carcinoembryonic antigen (CEA), and vimentin. The epithelial markers stained 93 per cent of the chordomas, whereas none of the tumors of other types showed any staining. Sixty-four per cent of the chordomas, 20 per cent of the myxoid chondrosarcomas, and 87 per cent of the other chondroid tumors were positive for S-100 protein. All of the tumors were positive for vimentin. Three of the 14 chordomas were positive for CEA. The present study confirms the utility of these markers in the differential diagnosis of chordoma and tumors with similar histologic characteristics.
对14例脊索瘤、5例黏液样软骨肉瘤和15例软骨样肿瘤（4例间叶性和11例传统型软骨肉瘤）进行细胞角蛋白、S-100蛋白、癌胚抗原（CEA）和波形蛋白染色。上皮标志物在93%的脊索瘤中呈阳性染色，而其他类型的肿瘤均未显示任何染色。64%的脊索瘤、20%的黏液样软骨肉瘤和87%的其他软骨样肿瘤S-100蛋白呈阳性。所有肿瘤波形蛋白均呈阳性。14例脊索瘤中有3例CEA呈阳性。本研究证实了这些标志物在脊索瘤和具有相似组织学特征的肿瘤鉴别诊断中的作用。
