Meis J M, Giraldo A A
Department of Pathology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston.
Arch Pathol Lab Med. 1988 May;112(5):553-6.
Twenty chordomas from 20 patients, including 17 nonchondroid and three chondroid types, were studied with a variety of antibodies directed against cytokeratin (AE-1/3), epithelial membrane antigen, carcinoembryonic antigen, S100 protein, vimentin, alpha 1-antichymotrypsin, and lysozyme. All 17 nonchondroid chordomas stained for cytokeratin, and most (16) stained for epithelial membrane antigen. In contrast, two chondroid chordomas failed to stain for either cytokeratin or epithelial membrane antigen, while one of them did stain for both antigens. Sixteen of the 20 chordomas (80%) stained for S100 protein, including all three chondroid chordomas. Vimentin was found in six (30%), and alpha 1-antichymotrypsin in 16 chordomas (80%). Carcinoembryonic antigen and lysozyme were each found in two specimens (10%). While these findings basically agree with the immunohistochemical studies of other investigators, there are a few discrepancies. Most significant is the lack of epithelial markers in two of three chondroid chordomas located at the base of the skull. Possible reasons for the discrepancies are discussed.
对来自20例患者的20例脊索瘤进行了研究，其中包括17例非软骨样型和3例软骨样型，使用了多种针对细胞角蛋白（AE-1/3）、上皮膜抗原、癌胚抗原、S100蛋白、波形蛋白、α1-抗糜蛋白酶和溶菌酶的抗体。所有17例非软骨样脊索瘤均呈细胞角蛋白染色阳性，大多数（16例）呈上皮膜抗原染色阳性。相比之下，2例软骨样脊索瘤细胞角蛋白和上皮膜抗原染色均为阴性，而其中1例两种抗原染色均为阳性。20例脊索瘤中有16例（80%）呈S100蛋白染色阳性，包括所有3例软骨样脊索瘤。波形蛋白在6例（30%）中被发现，α1-抗糜蛋白酶在16例脊索瘤（80%）中被发现。癌胚抗原和溶菌酶在两个标本中各有发现（10%）。虽然这些发现与其他研究者的免疫组织化学研究基本一致，但仍存在一些差异。最显著的是位于颅底的3例软骨样脊索瘤中有2例缺乏上皮标志物。讨论了差异存在的可能原因。
