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TA10和2B3，单克隆抗体识别的HLA - DQ区域中的两个新等位基因。

TA10 and 2B3, two new alleles in the HLA-DQ region recognized by monoclonal antibodies.

作者信息

Schreuder G M, Maeda H, Koning F, D'Amaro J

出版信息

Hum Immunol. 1986 Jun;16(2):127-36. doi: 10.1016/0198-8859(86)90041-8.

DOI:10.1016/0198-8859(86)90041-8
PMID:2424871
Abstract

The monoclonal antibodies (MoAbs) A10/13 and IIB3 were studied in parallel with routine HLA-DR typings. The specificities TA10 and 2B3, recognized by A10/13 and IIB3 MoAb, respectively, showed clear segregation in families and never occurred together on the same haplotype. TA10 and 2B3 appeared to be in perfect Hardy-Weinberg equilibrium. The TA10 specificity is DQw3 related and is in linkage disequilibrium with DR5 (DRw11 and DRw12) and it is also weakly associated with DR4. The 2B3 specificity is DQw1 related and it is in linkage disequilibrium with DR2, DR4, DRw9, and DRw13. The 2B3 and TA10 specificities appear to be alleles of a polymorphic system, closely related, but different from HLA-DQ.

摘要

对单克隆抗体（MoAbs）A10/13和IIB3与常规HLA - DR分型进行了平行研究。分别由A10/13和IIB3单克隆抗体识别的特异性TA10和2B3，在家族中呈现明显的分离现象，且从未出现在同一条单倍型上。TA10和2B3似乎处于完美的哈迪 - 温伯格平衡状态。TA10特异性与DQw3相关，与DR5（DRw11和DRw12）处于连锁不平衡状态，并且与DR4也有弱关联。2B3特异性与DQw1相关，与DR2、DR4、DRw9和DRw13处于连锁不平衡状态。2B特异性和TA10特异性似乎是一个多态系统的等位基因，密切相关，但与HLA - DQ不同。

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Hum Immunol. 1986 Jun;16(2):127-36. doi: 10.1016/0198-8859(86)90041-8.
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引用本文的文献

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Immunochemistry of the HLA class II molecules isolated from a mouse cell transfected with DQ alpha and beta genes from a DR4 haplotype.从转染了DR4单倍型的DQα和β基因的小鼠细胞中分离出的HLA II类分子的免疫化学。
Immunogenetics. 1987;26(1-2):40-7. doi: 10.1007/BF00345453.
3
Molecular diversity of HLA-DQ. DQ alpha and beta chain isoelectric point differences and their relation to serologically defined HLA-DQ allospecificities.
HLA - DQ的分子多样性。DQα链和β链的等电点差异及其与血清学定义的HLA - DQ同种特异性的关系。
Immunogenetics. 1987;25(5):305-12. doi: 10.1007/BF00404423.
4
HLA-DQw3 dissected by cloned alloreactive T cells.
Immunogenetics. 1987;25(5):356-8. doi: 10.1007/BF00404431.
5
HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.通过单克隆抗体、等电点差异和限制性片段长度多态性检测到的与I型糖尿病抗性相关的HLA - DO多态性。
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6
Dissection of HLA class II haplotypes in HLA-DR4 homozygous individuals.HLA-DR4纯合个体中HLA II类单倍型的剖析。
Immunogenetics. 1986;23(5):333-40. doi: 10.1007/BF00398798.
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Polymorphisms of DQ beta genes in HLA-DR4 haplotypes from healthy and diabetic individuals.健康个体和糖尿病个体中HLA - DR4单倍型的DQβ基因多态性
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