Veeravarmal V, Madhavan R Nirmal, Nassar M Mohamed, Amsaveni R
Division of Oral and Maxillofacial Pathology, Rajah Muthaih Dental College and Hospital, Annamalai University, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2013 May;17(2):319. doi: 10.4103/0973-029X.119767.
The central odontogenic fibroma (COF) is a rare benign odontogenic mesenchymal tumor of jaw bones. The World Health Organization (WHO) recognizes two variants of COF namely: 1) Epithelial-rich type (WHO) and 2) epithelial-poor type (simple type). Rare variants like ossifying COF, COF associated with giant cell lesions, and amyloid have been documented. This article presents a case of an epithelial-rich variant of COF in a 24-year-old female. It presented as a bony swelling of the maxilla and appeared as a mixed lesion in radiographs. Histopathology showed a highly cellular fibrous connective tissue stroma with plump fibroblasts and long strands of odontogenic epithelium exhibiting mild eosinophilic to clear cytoplasm. Numerous cementum-like hematoxyphilic calcifications of various sizes akin to dentin or acellular cementum were observed. We believe that clinical and radiographic features of this case may add valuable knowledge to the already existing literature.
中央性牙源性纤维瘤（COF）是一种罕见的颌骨良性牙源性间充质肿瘤。世界卫生组织（WHO）认可COF的两种变体，即：1）上皮丰富型（WHO型）和2）上皮贫乏型（单纯型）。已记录到罕见的变体，如骨化性COF、与巨细胞病变相关的COF和淀粉样变。本文报告一例24岁女性上皮丰富型COF病例。它表现为上颌骨的骨质肿胀，在X线片上表现为混合性病变。组织病理学显示高度细胞性的纤维结缔组织基质，有成纤维细胞和长束状牙源性上皮，细胞质呈轻度嗜酸性至透明。观察到许多大小各异的类牙骨质嗜苏木精钙化，类似于牙本质或无细胞牙骨质。我们认为该病例的临床和影像学特征可能会为现有文献增添有价值的知识。
