Bhavin Vyas, Ruchi Vyas, Dd Santani
Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, India.
Iran J Pharm Res. 2011 Fall;10(4):795-8.
The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs test. All extracts except the petroleum ether extract showed significant increase (p < 0.001) in urine output. Urinary electrolyte excretion was also affected by the extracts: the alcoholic, ethyl acetate and n-butanol extract caused an increase in the urinary excretion of sodium and potassium ions. These findings suggest that among the mentioned extracts, ethanolic has the maximum diuretic activity followed by n-butanol extract.
将萝藦科植物大白牛角瓜的全株用50%乙醇进行提取，并用新鲜的植物材料依次用石油醚、乙酸乙酯和正丁醇进行提取，以测定其利尿活性。以速尿作为标准药物，采用利普希茨试验对大鼠口服给予400mg/Kg剂量的不同提取物的利尿活性进行评估。除石油醚提取物外，所有提取物的尿量均显著增加（p<0.001）。提取物也会影响尿电解质排泄：乙醇提取物、乙酸乙酯提取物和正丁醇提取物会导致尿中钠离子和钾离子排泄增加。这些发现表明，在上述提取物中，乙醇提取物的利尿活性最高，其次是正丁醇提取物。
