代谢综合征患者血清有机氯农药水平
Serum organochlorine pesticide levels in patients with metabolic syndrome.
作者信息
Tomar Laxmikant R, Agarwal Mukul P, Avasthi Rajnish, Tyagi Vipin, Mustafa Mohammad, Banerjee B D
机构信息
Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi, India.
出版信息
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S342-4. doi: 10.4103/2230-8210.119612.
INTRODUCTION
Organochlorine pesticides (OCPs) are endocrinal disruptors that tend to accumulate in adipose tissue and have been found to be associated with Metabolic Syndrome (MS).
AIM AND OBJECTIVES
- To measure serum OCP levels in patients of MS and control subjects, 2. To identify differences, if any, in serum OCP levels, in patients with MS and control subjects.
MATERIALS AND METHODS
Cross-sectional study was conducted in the Departments of Medicine and Biochemistry at University College of Medical Sciences (UCMS) and Guru Teg Bahadur Hospital (GTBH), Delhi. Nine OCPs [α-HCH (Hexachlorocyclohexane), β-HCH, g-HCH, α-endosulfan, β-endosulfan, aldrin, dieldrin, p, p'-DDT (Dichloro-diphenyl-trichloro-ethane), and p, p'-DDE (Dichloro-diphenyl-dichloro-ethylene)] were studied. Fifty subjects ≥18 years with MS (study group) and 50 age and sex-matched controls were included in the study.
EXCLUSION CRITERIA
(1) Persons having chronic occupational exposure to OCPs such as workers of pesticide factories, (2) Recent exposure to OCPs within 4 weeks.
RESULTS
Levels of all nine OCPs were higher in cases as compared to controls. However, only the mean value of β-HCH in cases (8.40 ± 8.64 ng/ml) was significantly (P < 0.001) higher as compared to controls (2.58 ± 2.34 ng/ml). After adjustment of confounding factors like age, sex, smoking, alcohol, and body mass index (BMI), only β-HCH and aldrin levels were positively and significantly associated with the risk of having MS. Adjusted Odds Ratio (OR) was 1.34 [CI = 1.14-1.57 (P < 0.001)] and 1.23 [CI = 1.01-1.50 (P = 0.045)], respectively.
CONCLUSION
There was a significant association of β- HCH and aldrin levels with MS.
引言
有机氯农药（OCPs）是内分泌干扰物，倾向于在脂肪组织中蓄积，并且已被发现与代谢综合征（MS）相关。
目的
- 测量MS患者和对照受试者的血清OCP水平；2. 确定MS患者和对照受试者血清OCP水平是否存在差异。
材料与方法
在德里大学医学院（UCMS）和古鲁·特格·巴哈杜尔医院（GTBH）的内科和生物化学科进行了横断面研究。研究了九种OCPs [α-六氯环己烷（α-HCH）、β-六氯环己烷（β-HCH）、γ-六氯环己烷（γ-HCH）、α-硫丹、β-硫丹、艾氏剂、狄氏剂、p, p'-滴滴涕（p, p'-DDT）和p, p'-二氯二苯乙烯（p, p'-DDE）]。研究纳入了50名年龄≥18岁的MS患者（研究组）和50名年龄及性别匹配的对照者。
排除标准
（1）有慢性职业性接触OCPs的人员，如农药厂工人；（2）在4周内近期接触过OCPs的人员。
结果
与对照组相比，所有九种OCPs在病例组中的水平均较高。然而，仅病例组中β-HCH的平均值（8.40±8.64 ng/ml）与对照组（2.58±2.34 ng/ml）相比有显著升高（P<0.001）。在调整年龄、性别、吸烟、饮酒和体重指数（BMI）等混杂因素后，仅β-HCH和艾氏剂水平与患MS的风险呈正相关且具有统计学意义。调整后的优势比（OR）分别为1.34 [CI = 1.14 - 1.57（P<0.001）]和1.23 [CI = 1.01 - 1.50（P = 0.045）]。
结论
β-HCH和艾氏剂水平与MS存在显著关联。
Zotero 插件