Tomar Laxmikant R, Agarwal Mukul P, Avasthi Rajnish, Tyagi Vipin, Mustafa Mohammad, Banerjee B D
Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi, India.
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S342-4. doi: 10.4103/2230-8210.119612.
Organochlorine pesticides (OCPs) are endocrinal disruptors that tend to accumulate in adipose tissue and have been found to be associated with Metabolic Syndrome (MS).
Cross-sectional study was conducted in the Departments of Medicine and Biochemistry at University College of Medical Sciences (UCMS) and Guru Teg Bahadur Hospital (GTBH), Delhi. Nine OCPs [α-HCH (Hexachlorocyclohexane), β-HCH, g-HCH, α-endosulfan, β-endosulfan, aldrin, dieldrin, p, p'-DDT (Dichloro-diphenyl-trichloro-ethane), and p, p'-DDE (Dichloro-diphenyl-dichloro-ethylene)] were studied. Fifty subjects ≥18 years with MS (study group) and 50 age and sex-matched controls were included in the study.
(1) Persons having chronic occupational exposure to OCPs such as workers of pesticide factories, (2) Recent exposure to OCPs within 4 weeks.
Levels of all nine OCPs were higher in cases as compared to controls. However, only the mean value of β-HCH in cases (8.40 ± 8.64 ng/ml) was significantly (P < 0.001) higher as compared to controls (2.58 ± 2.34 ng/ml). After adjustment of confounding factors like age, sex, smoking, alcohol, and body mass index (BMI), only β-HCH and aldrin levels were positively and significantly associated with the risk of having MS. Adjusted Odds Ratio (OR) was 1.34 [CI = 1.14-1.57 (P < 0.001)] and 1.23 [CI = 1.01-1.50 (P = 0.045)], respectively.
There was a significant association of β- HCH and aldrin levels with MS.
有机氯农药（OCPs）是内分泌干扰物，倾向于在脂肪组织中蓄积，并且已被发现与代谢综合征（MS）相关。
在德里大学医学院（UCMS）和古鲁·特格·巴哈杜尔医院（GTBH）的内科和生物化学科进行了横断面研究。研究了九种OCPs [α-六氯环己烷（α-HCH）、β-六氯环己烷（β-HCH）、γ-六氯环己烷（γ-HCH）、α-硫丹、β-硫丹、艾氏剂、狄氏剂、p, p'-滴滴涕（p, p'-DDT）和p, p'-二氯二苯乙烯（p, p'-DDE）]。研究纳入了50名年龄≥18岁的MS患者（研究组）和50名年龄及性别匹配的对照者。
（1）有慢性职业性接触OCPs的人员，如农药厂工人；（2）在4周内近期接触过OCPs的人员。
与对照组相比，所有九种OCPs在病例组中的水平均较高。然而，仅病例组中β-HCH的平均值（8.40±8.64 ng/ml）与对照组（2.58±2.34 ng/ml）相比有显著升高（P<0.001）。在调整年龄、性别、吸烟、饮酒和体重指数（BMI）等混杂因素后，仅β-HCH和艾氏剂水平与患MS的风险呈正相关且具有统计学意义。调整后的优势比（OR）分别为1.34 [CI = 1.14 - 1.57（P<0.001）]和1.23 [CI = 1.01 - 1.50（P = 0.045）]。
β-HCH和艾氏剂水平与MS存在显著关联。
