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转化医学成功的决定因素——一项管理方面的贡献。

The determinants of translational medicine success - a managerial contribution.

作者信息

Polese Francesco, Capunzo M

机构信息

Dept. of Business Studies (Management & Information Technology), University of Salerno, Italy - (

出版信息

Transl Med UniSa. 2013 May 6;6:29-34. eCollection 2013.

PMID:24251242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3829794/
Abstract

Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient's quality of life. Translational medicine represents the synergy between epidemiology, basic research and clinical trials, and is based upon Innovation Management and Research Development in medicine. Being the speed and progression up to the patient a key issue of Translational Medicine, the innovation process ought to be pursued according to rigorous protocols embedded on a research development path capable of decreasing the lead time at the most. Translational Medicine represents a goal to be pursued by all involved actors, from academic researchers to clinicians, patients and others than can be seen as a network of co-creating actors engaged for the ultimate patient benefit. To underpin Translational Medicine advantages and determinants, the paper approaches the issue by adopting a systems thinking perspective, capable of highlighting the key issues to be considered.

摘要

转化医学的范围是加快新的医学方案和/或治疗化合物的开发,以提高患者的生活质量。转化医学代表了流行病学、基础研究和临床试验之间的协同作用,并且基于医学中的创新管理和研究发展。由于速度和向患者推进是转化医学的关键问题,创新过程应根据严格的方案来进行,这些方案嵌入在能够最大程度缩短前置时间的研究发展路径中。转化医学是所有相关参与者(从学术研究人员到临床医生、患者以及其他可被视为共同创造的参与者网络)都应追求的目标,其目的是最终使患者受益。为了支持转化医学的优势和决定因素,本文采用系统思维视角来探讨这个问题,这种视角能够突出需要考虑的关键问题。

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本文引用的文献

1
To be or not to be translational.是否具有转化性。
Transl Med UniSa. 2013 Jan 4;5:5-6. Print 2013 Jan.
2
A new vision of definition, commentary, and understanding in clinical and translational medicine.临床与转化医学的新定义、新诠释和新理解。
Clin Transl Med. 2012 May 3;1(1):5. doi: 10.1186/2001-1326-1-5.
3
A decade plus of translation: what do we understand?十余年的翻译实践:我们了解多少?
Clin Transl Med. 2012 Mar 30;1(1):3. doi: 10.1186/2001-1326-1-3.
4
Clinical and translational medicine: Integrative and practical science.临床与转化医学:整合性与实用性科学。
Clin Transl Med. 2012 Mar 29;1(1):1. doi: 10.1186/2001-1326-1-1.
5
Network analysis of drug prescriptions.药物处方的网络分析。
Pharmacoepidemiol Drug Saf. 2013 Feb;22(2):130-7. doi: 10.1002/pds.3384. Epub 2012 Nov 26.
6
Biomedical informatics and translational medicine.生物医学信息学与转化医学。
J Transl Med. 2010 Feb 26;8:22. doi: 10.1186/1479-5876-8-22.
7
Models of consumer value cocreation in health care.医疗保健中的消费者价值共创模型。
Health Care Manage Rev. 2009 Oct-Dec;34(4):344-54. doi: 10.1097/HMR.0b013e3181abd528.
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The meaning of translational research and why it matters.转化研究的意义及其重要性。
JAMA. 2008 Jan 9;299(2):211-3. doi: 10.1001/jama.2007.26.
9
Implementing managerial innovations in primary care: can we rank change drivers in complex adaptive organizations?在初级保健中实施管理创新:我们能否对复杂适应性组织中的变革驱动因素进行排名?
Health Care Manage Rev. 2007 Jul-Sep;32(3):213-25. doi: 10.1097/01.HMR.0000281620.13116.ce.
10
What's next in translational medicine?转化医学的下一步是什么?
Clin Sci (Lond). 2007 Feb;112(4):217-27. doi: 10.1042/CS20060108.