Brackman G, Forier K, Al Quntar A A A, De Canck E, Enk C D, Srebnik M, Braeckmans K, Coenye T
Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
J Appl Microbiol. 2014 Mar;116(3):492-501. doi: 10.1111/jam.12378. Epub 2013 Nov 20.
The aim of the present study was to determine the effect of two thiazolidinedione derivatives on Propionibacterium acnes biofilm formation in vitro and to assess their effect on the susceptibility of P. acnes biofilms towards antimicrobials.
The compounds were shown to have a moderate to strong antibiofilm activity when used in subinhibitory concentrations. These compounds do not affect P. acnes attachment but lead to increased dispersal of biofilm cells. This dispersal results in an increased killing of the P. acnes biofilm cells by conventional antimicrobials.
The antibiofilm effect and the effect on biofilm susceptibility of the thiazolidinedione-derived quorum sensing inhibitors were clearly demonstrated.
Propionibacterium acnes infections are difficult to treat due to the presence of biofilms at the infection site and the associated resistance towards conventional antimicrobials. Our results indicate that these thiazolidinedione derivatives can be promising leads used for the treatment of P. acnes infections and as anti-acne drugs.
本研究旨在确定两种噻唑烷二酮衍生物对痤疮丙酸杆菌生物膜体外形成的影响，并评估它们对痤疮丙酸杆菌生物膜对抗菌药物敏感性的影响。
当以亚抑制浓度使用时，这些化合物显示出中度至强的抗生物膜活性。这些化合物不影响痤疮丙酸杆菌的附着，但会导致生物膜细胞的分散增加。这种分散导致传统抗菌药物对痤疮丙酸杆菌生物膜细胞的杀伤增加。
噻唑烷二酮衍生的群体感应抑制剂的抗生物膜作用及其对生物膜敏感性的影响得到了明确证明。
由于感染部位存在生物膜以及对传统抗菌药物的相关耐药性，痤疮丙酸杆菌感染难以治疗。我们的结果表明，这些噻唑烷二酮衍生物有望用于治疗痤疮丙酸杆菌感染并作为抗痤疮药物。
