GT-肽10和柠檬酸三乙酯对痤疮丙酸杆菌生物膜形成、活力及分散的影响。
Effect of GT-Peptide 10 and Triethyl Citrate on <em>P. acnes</em> Biofilm Formation, Viability, and Dispersion.
作者信息
Eilers Hinnerk, Alexeyev Oleg A
出版信息
J Drugs Dermatol. 2016 Jun 1;15(6):778-81.
BACKGROUND
P. acnes biofilms are emerging topics in acne vulgaris pathogenesis and may be responsible for antibiotic tolerance.
OBJECTIVE
To investigate the efficacy of GT peptide 10 either alone or in combination with triethyl citrate (TEC) in in vitro model of P. acnes biofilm.
METHODS
Six-day-old P. acnes biofilms were treated with various concentrations of these substances and biofilm dispersion and cell viability were monitored.
RESULTS
A 24-hour exposure of preformed biofilms to a combination of GT peptide 10/TEC led to killing of up to 92% of bacterial cells inside the biofilm. Neither the single substance nor the combination of both substances affected the biofilm integrity or resulted in biofilm dispersal.
CONCLUSIONS
A combination of GT peptide 10/TEC shows antibacterial effects in in vitro model of P. acnes biofilm.
J Drugs Dermatol. 2016;15(6):778-781.
背景
痤疮丙酸杆菌生物膜是寻常痤疮发病机制中的新兴话题，可能与抗生素耐受性有关。
目的
研究GT肽10单独使用或与柠檬酸三乙酯（TEC）联合使用在痤疮丙酸杆菌生物膜体外模型中的疗效。
方法
用不同浓度的这些物质处理6日龄的痤疮丙酸杆菌生物膜，并监测生物膜的分散情况和细胞活力。
结果
将预先形成的生物膜暴露于GT肽10/TEC组合24小时，可杀死生物膜内高达92%的细菌细胞。单一物质或两种物质的组合均未影响生物膜的完整性，也未导致生物膜分散。
结论
GT肽10/TEC组合在痤疮丙酸杆菌生物膜体外模型中显示出抗菌作用。
《皮肤用药杂志》2016年；15(6):778 - 781。
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