Kinetic Concepts, Inc., San Antonio, TX, USA.
Int Wound J. 2013 Dec;10 Suppl 1(Suppl 1):20-4. doi: 10.1111/iwj.12171.
A new method (V.A.C.ULTA Therapy System, KCI USA, Inc., San Antonio, TX) combines the benefits of negative pressure wound therapy (NPWT; V.A.C. Therapy, KCI USA, Inc.) with regulated, periodic instillation of user-selected topical wound solutions (V.A.C. VeraFlo Therapy, KCI USA, Inc.). In simulated wound model studies comparing solution distribution using NPWT with and without a soak phase, the instillation soak phase allowed for uniform solution distribution across the wound bed, whereas continuous (no soak) irrigation resulted in uneven coverage. Additional in vitro work illustrated that bacterial particle aerosolisation during wound cleansing was significantly decreased using NPWT with instillation (NPWTi) versus commercially available low-pressure wound cleansers (P < 0·05). In porcine studies, NPWT with saline instillation induced 43% more granulation tissue versus NPWT (P < 0·05) and was as effective at wound cleansing as pulsed lavage. These studies have demonstrated that NPWTi may be an effective wound management therapy that provides both wound cleansing and NPWT benefits.
一种新方法（V.A.C.ULTA 治疗系统，美国 KCI，圣安东尼奥，TX）结合了负压伤口治疗（NPWT；V.A.C. 治疗，美国 KCI，Inc.）和用户选择的局部伤口溶液的定期、周期性灌输的优点（V.A.C. VeraFlo 治疗，美国 KCI，Inc.）。在模拟伤口模型研究中，比较 NPWT 有无浸泡阶段的溶液分布，浸泡阶段允许溶液在整个伤口床上均匀分布，而连续（无浸泡）灌溉则导致覆盖不均匀。额外的体外研究表明，在伤口清洗过程中，细菌颗粒气溶胶化的程度使用带灌输的 NPWT（NPWTi）比市售的低压伤口清洁剂显著降低（P < 0·05）。在猪的研究中，与 NPWT 相比，盐水灌输的 NPWT 诱导 43%更多的肉芽组织（P < 0·05），并且与脉冲冲洗一样有效清洁伤口。这些研究表明，NPWTi 可能是一种有效的伤口管理治疗方法，同时提供伤口清洗和 NPWT 的益处。
