受历史范式的阻碍——棘白菌素与念珠菌性心内膜炎的治疗
Hampered by historical paradigms--echinocandins and the treatment of Candida endocarditis.
作者信息
Gardiner B J, Slavin M A, Korman T M, Stuart R L
机构信息
Monash Infectious Diseases, Monash Medical Centre, Clayton, Vic., Australia.
出版信息
Mycoses. 2014 May;57(5):316-9. doi: 10.1111/myc.12154. Epub 2013 Nov 20.
PMID:24251958
Abstract
Infective endocarditis due to Candida sp. has a high mortality rate. Traditionally, management involves early surgery and prolonged amphotericin ± flucytosine. We report a case of Candida parapsilosis bileaflet mitral valve endocarditis cured with anidulafungin and fluconazole, and review the role of echinocandins in the management of Candida endocarditis.
摘要
念珠菌属引起的感染性心内膜炎死亡率很高。传统上，治疗方法包括早期手术以及长期使用两性霉素±氟胞嘧啶。我们报告一例近平滑念珠菌双叶二尖瓣心内膜炎患者，经阿尼芬净和氟康唑治愈，并综述棘白菌素类药物在念珠菌性心内膜炎治疗中的作用。
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