联合抗真菌治疗人工瓣膜心内膜炎及T2Candida Panel®的应用：病例系列
Combination antifungal therapy for treatment of prosthetic valve endocarditis and utility of T2Candida Panel®: A case series.
作者信息
Ahuja Tania, Fong Karen, Louie Eddie
机构信息
New York University Langone Health, Department of Pharmacy, 550 First Avenue, New York, NY 10016, United States.
University of Maryland St. Joseph Medical Center, Department of Pharmacy, 7601 Osler Dr, Towson, MD 21204, United States.
出版信息
IDCases. 2019 Mar 19;15:e00525. doi: 10.1016/j.idcr.2019.e00525. eCollection 2019.
Abstract
Although Candida species are common pathogens for nosocomial infections, Candida endocarditis is still considered a rare entity. Here, we report two cases of endovascular infections in patients with prosthetic valves, both of which responded to combination antifungal therapy without surgical intervention. Additionally, T2 magnetic resonance (T2MR) was used to assess for resolution of invasive candidiasis. The first case is of an elderly man with endovascular infection who responded to combination antifungal therapy with micafungin and fluconazole followed by suppressive therapy, without surgical intervention. The second case is of a middle-aged man with prosthetic valve endocarditis who also responded to combination antifungal therapy with micafungin, flucytosine and fluconazole, without surgical intervention.
摘要
虽然念珠菌属是医院感染的常见病原体，但念珠菌性心内膜炎仍被认为是一种罕见疾病。在此，我们报告两例人工瓣膜患者发生的血管内感染病例，两例均对联合抗真菌治疗有反应，无需手术干预。此外，使用T2磁共振成像（T2MR）评估侵袭性念珠菌病的消退情况。第一例是一名患有血管内感染的老年男性，对米卡芬净和氟康唑联合抗真菌治疗有反应，随后接受抑制性治疗，无需手术干预。第二例是一名患有人工瓣膜心内膜炎的中年男性，对米卡芬净、氟胞嘧啶和氟康唑联合抗真菌治疗也有反应，无需手术干预。
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