Mair R G, Langlais P J, Mazurek M F, Beal M F, Martin J B, McEntee W J
Life Sci. 1986 Jun 23;38(25):2301-6. doi: 10.1016/0024-3205(86)90636-3.
The concentrations of arginine vasopressin (AVP), somatostatin (SS), and the primary brain metabolites of norepinephrine (MHPG), serotonin (5-HIAA), and dopamine (HVA) were measured in samples of lumbar CSF obtained from ten amnesics with Korsakoff's psychosis, four patients with a history of Korsakoff's psychosis who had recovered from the amnesic symptoms of this disease, and control subjects. Significant deficits were observed in the amnesic group for AVP and MHPG, but not for the other substances measured. Subjects who had recovered from the amnesic symptoms of Korsakoff's psychosis had increased concentrations of AVP and MHPG, but not of SS or the other monoamine metabolites.
在从10名患有柯萨科夫精神病的遗忘症患者、4名有柯萨科夫精神病病史且已从该病遗忘症状中康复的患者以及对照受试者身上采集的腰椎脑脊液样本中，测量了精氨酸加压素（AVP）、生长抑素（SS）以及去甲肾上腺素的主要脑代谢产物（MHPG）、5-羟色胺（5-HIAA）和多巴胺（HVA）的浓度。在遗忘症组中观察到AVP和MHPG有显著缺乏，但所测量的其他物质则没有。已从柯萨科夫精神病遗忘症状中康复的受试者，其AVP和MHPG浓度升高，但SS或其他单胺代谢产物的浓度未升高。
