Xu Lei, Zhou Xin, Jiang Feng, Xu Lin, Yin Rong
The Fourth Clinical College of Nanjing Medical University, China; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, China.
Department of Oncology, First Clinical College of Nanjing Medical University, Nanjing 210029, China.
Cancer Epidemiol. 2014 Apr;38(2):111-7. doi: 10.1016/j.canep.2013.10.008. Epub 2013 Nov 16.
It has been suggested that the serine/threonine kinase 15 (STK15) T91A rs2273535 polymorphism is associated with susceptibility to cancer. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship.
PubMed was searched to select studies. Case-control studies containing available genotype frequencies of the STK15 rs2273535 polymorphism were chosen, and the odds ratio (OR) with its 95% confidence interval (CI) was utilized to assess the strength of association.
52 studies - including 34,057 cases and 40,839 controls - were identified. A significant effect of the STK15 rs2273535 polymorphism on cancer risk was found (AA vs. TT: OR=1.13, 95%CI=1.01-1.26, Pheterogeneity<0.001; AA vs.
TA/TT: OR=1.12, 95%CI=1.02-1.22, Pheterogeneity<0.001; TA/AA vs. TT: OR=1.06, 95%CI=1.01-1.12, Pheterogeneity<0.001). Stratified analysis by cancer type revealed that the STK rs2273535 polymorphism may contribute to the risk of breast cancer (AA vs. TT: OR=1.21, 95%CI=1.01-1.44, Pheterogeneity=0.002), colorectal cancer (AA vs.
TA/TT: OR=1.24, 95%CI=1.05-1.47, Pheterogeneity=0.124), and esophageal cancer (AA vs.
TA/TT: OR=1.19, 95%CI=1.02-1.39, Pheterogeneity=0.148). Further subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians (AA vs.
TA/TT: OR=1.20, 95%CI=1.05-1.37, Pheterogeneity=0.004).
This meta-analysis suggests that the STK15 rs2273535 polymorphism is a candidate gene polymorphism for cancer susceptibility, especially in Asian populations.
有研究表明，丝氨酸/苏氨酸激酶15（STK15）T91A rs2273535多态性与癌症易感性相关。然而，研究结果相互矛盾。我们进行了这项荟萃分析，以更精确地评估两者之间的关系。
检索PubMed以选择研究。选取包含STK15 rs2273535多态性可用基因型频率的病例对照研究，并利用比值比（OR）及其95%置信区间（CI）来评估关联强度。
共纳入52项研究，包括34057例病例和40839例对照。发现STK15 rs2273535多态性对癌症风险有显著影响（AA与TT比较：OR = 1.13，95%CI = 1.01 - 1.26，异质性P<0.001；AA与TA/TT比较：OR = 1.12，95%CI = 1.02 - 1.22，异质性P<0.001；TA/AA与TT比较：OR = 1.06，95%CI = 1.01 - 1.12，异质性P<0.001）。按癌症类型进行分层分析显示，STK rs2273535多态性可能与乳腺癌风险有关（AA与TT比较：OR = 1.21，95%CI = 1.01 - 1.44，异质性P = 0.002）、结直肠癌（AA与TA/TT比较：OR = 1.24，95%CI = 1.05 -
