Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, China.
PLoS One. 2013 Dec 13;8(12):e82790. doi: 10.1371/journal.pone.0082790. eCollection 2013.
The association between the Serine/threonine kinase 15 (STK15) F31I polymorphism (rs2273535) and cancer susceptibility remains controversial. To further investigate this potential relationship, we conducted a comprehensive meta-analysis of 27 published studies involving a total of 19,267 multiple cancer cases and 24,359 controls. Our results indicate statistical evidence of an association between the STK15 F31I polymorphism and the increased risk of overall cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T. In a stratified analysis by cancer type, there was an increased risk of breast cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T, as well as esophageal cancer in two genetic models: AA vs. TA+TT and AA vs. TA. In a stratified analysis by ethnicity, there was a significant increase in cancer risk among Asians, but not Caucasians, in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA and A vs. T. In addition, a stratified analysis by ethnicity in the breast cancer subgroup revealed a significant increase in cancer risk among Asians in two genetic models: AA vs. TA+TT and AA vs. TT, as well as among Caucasians in one genetic model: AA vs. TA. In summary, this meta-analysis demonstrates that the STK15 F31I polymorphism may be a risk factor for cancer.
丝氨酸/苏氨酸激酶 15（STK15）F31I 多态性（rs2273535）与癌症易感性之间的关系仍存在争议。为了进一步研究这种潜在的关系，我们对 27 项已发表的研究进行了综合荟萃分析，这些研究共涉及 19267 例多种癌症病例和 24359 例对照。我们的研究结果表明，在四种遗传模型中，STK15 F31I 多态性与总体癌症风险增加存在统计学关联：AA 与 TA+TT、AA 与 TT、AA 与 TA 和 A 与 T。按癌症类型分层分析显示，在四种遗传模型中，乳腺癌风险增加：AA 与 TA+TT、AA 与 TT、AA 与 TA 和 A 与 T，以及在两种遗传模型中，食管癌风险增加：AA 与 TA+TT 和 AA 与 TA。按种族分层分析显示，在四种遗传模型中，亚洲人群癌症风险显著增加：AA 与 TA+TT、AA 与 TT、AA 与 TA 和 A 与 T，但在高加索人群中没有增加。此外，在乳腺癌亚组的种族分层分析中发现，在两种遗传模型中，亚洲人群癌症风险显著增加：AA 与 TA+TT 和 AA 与 TT，以及在一种遗传模型中，高加索人群癌症风险增加：AA 与 TA。总之，这项荟萃分析表明，STK15 F31I 多态性可能是癌症的一个风险因素。
