Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil; Universidade Federal da Fronteira Sul (UFFS), Campus Cerro Largo, Avenida Jacob Reinaldo Haupenthal, n 1580, Cerro Largo 97900-000, RS, Brazil.
Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, n 9500, Porto Alegre 91501-970, RS, Brazil.
Food Chem Toxicol. 2014 Jan;63:205-11. doi: 10.1016/j.fct.2013.11.002. Epub 2013 Nov 16.
We have previously demonstrated that quercetin (Quer), a polyphenol widely found in vegetables, decreased glioma cell growth in vitro. Here, we asked whether this compound could affect glioma growth in an in vivo rat glioma model. We found that daily intraperitoneal Quer (50 mg/kg) injections lead to a concentration of 0.15 μg of Quer per gram of brain tissue, which increased the tumor volume in a time dependent manner. We observed a small reduction in lymphocytic infiltration, a marker of good prognosis in gliomas that was accompanied by a small reduction in cell viability of peripheral T-cells. Moreover, after Quer treatment neither body weight alteration nor liver pathology markers were detected. Although in vitro studies and massive literature reports point to the antitumoral properties of Quer, the present results indicate that great caution has to be taken in the design of clinical trials and the indiscriminate use of this polyphenol as dietary supplement.
我们之前已经证明，广泛存在于蔬菜中的多酚类化合物槲皮素（Quer）可抑制体外神经胶质瘤细胞生长。在这里，我们研究了该化合物是否可以影响体内大鼠神经胶质瘤模型中的神经胶质瘤生长。我们发现，每天腹腔注射槲皮素（50mg/kg）可使脑组织中的槲皮素浓度达到 0.15μg/g，且呈时间依赖性地增加肿瘤体积。我们观察到淋巴细胞浸润减少，这是神经胶质瘤预后良好的标志物，同时外周 T 细胞的活力也略有下降。此外，槲皮素治疗后未检测到体重变化或肝病理标志物的改变。尽管体外研究和大量文献报道表明槲皮素有抗肿瘤特性，但目前的结果表明，在临床试验的设计和将这种多酚类化合物作为膳食补充剂的随意使用方面必须非常谨慎。
