CONACYT-Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
Molecules. 2020 Nov 28;25(23):5597. doi: 10.3390/molecules25235597.
Oxidative stress is a crucial event underlying several pediatric neurological diseases, such as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Neuroprotective therapy with natural compounds used as antioxidants has the potential to delay, ameliorate or prevent several pediatric neurological diseases. The present review provides an overview of the most recent research outcomes following quercetin treatment for CNS tumors, ASD and ADHD as well as describes the potential in vitro and in vivo ameliorative effect on oxidative stress of bioactive natural compounds, which seems like a promising future therapy for these diseases. The neuroprotective effects of quercetin against oxidative stress can also be applied in the management of several neurodegenerative disorders with effects such as anti-cancer, anti-inflammatory, anti-viral, anti-obesity and anti-microbial. Therefore, quercetin appears to be a suitable adjuvant for therapy against pediatric neurological diseases.
氧化应激是几种儿科神经疾病的关键事件，如中枢神经系统 (CNS) 肿瘤、自闭症谱系障碍 (ASD) 和注意缺陷/多动障碍 (ADHD)。使用抗氧化剂的天然化合物进行神经保护治疗有可能延迟、改善或预防几种儿科神经疾病。本综述提供了槲皮素治疗 CNS 肿瘤、ASD 和 ADHD 的最新研究结果概述，并描述了生物活性天然化合物对氧化应激的潜在体外和体内改善作用，这似乎是这些疾病有前途的未来治疗方法。槲皮素对氧化应激的神经保护作用也可应用于几种神经退行性疾病的治疗，具有抗癌、抗炎、抗病毒、抗肥胖和抗微生物等作用。因此，槲皮素似乎是治疗儿科神经疾病的一种合适的辅助药物。
