Woolf C, Wiesenfeld-Hallin Z
Neurosci Lett. 1986 May 15;66(2):226-30. doi: 10.1016/0304-3940(86)90195-3.
A comparison has been made between the effects of intrathecally administered L-glutamate, L-aspartate, substance P and calcitonin gene-related peptide (CGRP) on the excitability of rat flexor alpha-motoneurons activated monosynaptically by Ia afferents and polysynaptically by high mechano-threshold cutaneous afferents. At doses that do not modify the monosynaptic reflex, substance P, CGRP and some factor released from sural C-fibres increase the excitability of the nociceptive flexion reflex for prolonged periods in a multiplicative fashion. The excitatory amino acids have no such action. We suggest that one role for C-afferent neuropeptides is a long-acting gain modulation of nociceptive inputs into the spinal cord.
已对鞘内注射L-谷氨酸、L-天冬氨酸、P物质和降钙素基因相关肽（CGRP）对大鼠屈肌α运动神经元兴奋性的影响进行了比较，这些运动神经元由Ia传入纤维单突触激活以及由高机械阈值皮肤传入纤维多突触激活。在不改变单突触反射的剂量下，P物质、CGRP和来自腓肠C纤维释放的某些因子以相乘方式长时间增加伤害性屈曲反射的兴奋性。兴奋性氨基酸没有这种作用。我们认为C传入神经肽的一个作用是对脊髓中伤害性传入进行长效增益调节。
