Noninvasive techniques for measuring body elemental composition : State of the art and future prospects.

In the past 20 yr, in vivo analysis of body elements by neutron activation has become an important tool in medical research. In particular, it provides a much needed means to make quantitative assessments of body composition of human beings in vivo. The data are useful both for basic physiological understanding and for diagnosis and management of a variety of diseases and disorders. This paper traces the development of the in vivo neutron activation technique from basic systems to the present state of the art facilities. A scan of some of the numerous clinical applications that have been made with this technique reveals the broad potentialities of in vivo neutron activation. The paper also considers alternative routes of future development and raises some of the questions now faced in making the technique more widely available to both medical practitioners and medical investigtors.In vivo neutron activation has opened a new era of both clinical diagnosis and therapy evaluation, and investigation into the modeling of body composition. The techniques are new, but it is already clear that considerable strides can be made in increasing accuracy and precision, increasing the number of elements susceptible to measurement, and reducing the dose required for the measurement.