Department of Medicine, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road, BT12 6BJ, Belfast, N. Ireland.
Biol Trace Elem Res. 1987 Oct;14(1-2):65-77. doi: 10.1007/BF02795597.
Trientine((R)) is not an effective drug for the treatment of intractable hand dermatitis in nickel-sensitive patients. In a controlled, double-blind study this chelator, on oral administration, failed to stimulate nickel excretion. Early morning urine samples from two groups of nine patients were analyzed by atomic absorption spectrophotometry in a stabilized Temperature Platform Furnace equipped with Zeeman background correction. Group 1 patients received placebo for 6 wk, then a 4-wk rest before crossover. Group 2 received the drug in the first period. No difference in Ni levels between the placebo period and the drug period in either group was demonstrated, nor was there any significant improvement in the hand eczema.Copper was measured in the same urine samples using the same instrumentation, but with atomization off the wall. There was a considerable increase in copper excretion during the drug treatment period. Group 1 excreted a mean 538±378 (SD) μg/L, which represented a mean increase of 787±653 % (SD). Group 2 excreted a mean 960±410 (SD) μg/L; a mean difference of 630±398 % (SD). It was concluded that the use of Trientine((R)) in subjects of normal copper status should be carefully controlled and monitored.
三乙膦酸（R）作为一种螯合剂，在口服给药时，对镍敏感患者的顽固性手部皮炎没有治疗效果，不能刺激镍的排泄。在一项对照、双盲研究中，采用稳定温度平台炉和 Zeeman 背景校正，通过原子吸收分光光度法对两组各 9 名患者的清晨尿液样本进行分析。第 1 组患者先服用安慰剂 6 周，然后停药 4 周再交叉。第 2 组患者在第一阶段服用药物。两组患者的镍水平在安慰剂期和药物期之间均无差异，手部湿疹也没有明显改善。在相同的尿液样本中，用相同的仪器测量铜，但将雾化器移到炉壁之外。在药物治疗期间，铜的排泄量显著增加。第 1 组平均排泄 538±378μg/L，平均增加 787±653%（SD）。第 2 组平均排泄 960±410μg/L，平均差异为 630±398%（SD）。结论：对于铜含量正常的患者，应谨慎控制和监测三乙膦酸（R）的使用。
