锂治疗后出现银屑病样综合征。

Development of a psoriasis-like syndrome following lithium therapy.

机构信息

Department of Dermatology, Hirosaki University, School of Medicine, Hirosaki, Japan.

出版信息

Biol Trace Elem Res. 1987 Dec;14(3):169-77. doi: 10.1007/BF02795684.

Abstract

A correlation between lithium and psoriasis has been observed. In this paper, the case of a 17-yr-old girl is reported who developed psoriatic lesions after administration of lithium carbonate. Further-more, serum lithium levels in some psoriatic patients are disclosed, and induction of psoriasis by lithium in experimental animals is described. Serum lithium levels in 27 patients were significantly higher (p<0.025) than those of controls. Uninvolved parts of skin tissues obtained from three cases of psoriasis were transplanted to nude mice. After supplementing lithium as the chloride, these skin grafts developed the histologic change characteristic of psoriasis. However, the lithium compound by itself did not increase superoxide production of polymorphonuclear leukocytes in psoriasis.

摘要

锂与银屑病之间存在相关性。本文报道了一例 17 岁女孩在服用碳酸锂后出现银屑病皮损的病例。此外，还揭示了一些银屑病患者的血清锂水平，并描述了锂在实验动物中诱导银屑病的情况。27 例患者的血清锂水平明显高于对照组(p<0.025)。从三例银屑病患者的非皮损皮肤组织中获取组织，移植到裸鼠体内。补充氯化锂后，这些皮肤移植物发生了具有银屑病特征的组织学变化。然而，锂化合物本身并不能增加银屑病中性粒细胞的超氧化物产生。