Sedgwick J B, Bergstresser P R, Hurd E R
J Invest Dermatol. 1980 Feb;74(2):81-4. doi: 10.1111/1523-1747.ep12519947.
Circulating polymorphonuclear leukocytes (PMN) from patients with psoriasis and psoriatic arthritis were found to be significantly more adherent to nylon fiber columns when compared with both normal and nonpsoriatic patient control groups. The increased adherence correlated positively with the extent of disease and was highest in those patients with psoriatic arthritis. Total leukocyte and PMN counts were increased in psoriasis patients and were highest in the psoriatic arthritis group. No increase in cell counts was found for mononuclear leukocytes. PMN adherence was not increased in lithium-treated patients or a nonpsoriatic patient control group although such patients did have significant granulocytosis. PMN's are frequently present in lesions of psoriasis as are activated complement components and abnormal keratinocyte cyclic nucleotide levels. These factors or others may cause a generalized activation of PMN's in psoriasis leading to migration of neutrophils into the skin lesion. The present study demonstrates a systemic effector cell alteration in psoriasis and contradicts the general concept that uncomplicated psoriasis is limited to the skin.
与正常对照组和非银屑病患者对照组相比，银屑病和银屑病关节炎患者的循环多形核白细胞（PMN）对尼龙纤维柱的黏附性明显更高。黏附性增加与疾病程度呈正相关，在银屑病关节炎患者中最高。银屑病患者的总白细胞和PMN计数增加，在银屑病关节炎组中最高。单核白细胞计数未增加。锂治疗患者或非银屑病患者对照组的PMN黏附性未增加，尽管这些患者确实有明显的粒细胞增多。PMN以及活化的补体成分和异常的角质形成细胞环核苷酸水平经常出现在银屑病皮损中。这些因素或其他因素可能导致银屑病中PMN的普遍活化，从而导致中性粒细胞迁移到皮肤病变中。本研究证明了银屑病中存在系统性效应细胞改变，这与单纯银屑病仅限于皮肤的一般概念相矛盾。
