Di Roberto Raphael B, Peisajovich Sergio G
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
J Exp Zool B Mol Dev Evol. 2014 Feb;322(2):65-72. doi: 10.1002/jez.b.22551. Epub 2013 Nov 19.
In a seminal paper entitled "Evolution and Tinkering," François Jacob affirmed that: "Novelties come from previously unseen association of old material. To create is to recombine" [Jacob F. (1977) Science 196:1161-1166]. In the 35 years that have passed since Jacob's insight, we have amassed enough data to actually shed light on many of the molecular mechanisms that enable evolution to create novelty by simply recombining what existed already. In this review, we will succinctly discuss the role that the recombination of protein domains has in the evolution of signaling networks, drawing from examples provided by diverse disciplines, including bioinformatics, systems and synthetic biology, and laboratory evolution.
在一篇题为《进化与修补》的开创性论文中，弗朗索瓦·雅各布断言：“新奇事物源自旧有物质此前未被发现的组合。创造就是重新组合”[雅各布F.（1977年）《科学》196:1161 - 1166]。自雅各布提出这一见解后的35年里，我们积累了足够的数据，得以切实阐明许多分子机制，这些机制使进化能够通过简单地重新组合已有的物质来创造新奇事物。在本综述中，我们将从生物信息学、系统与合成生物学以及实验室进化等不同学科提供的实例出发，简要讨论蛋白质结构域的重组在信号网络进化中所起的作用。
