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胺碘酮致肺毒性的极早发病。

Very early onset of amiodarone-induced pulmonary toxicity.

机构信息

Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.

出版信息

Korean Circ J. 2013 Oct;43(10):699-701. doi: 10.4070/kcj.2013.43.10.699. Epub 2013 Oct 30.

Abstract

Amiodarone is a widely used antiarrhythmic agent. Among its various adverse effects, amiodarone-induced pulmonary toxicity (APT) is the most life threatening complication, which has been described mostly in patients who have been in treatment with high accumulative doses for a long duration of time. However, amiodarone therapy in short-term duration induced APT was rarely reported. We describe a case of a 54-year-old man who is presented with symptoms of APT after a few days of therapy for post-myocardial infarction ventricular tachycardia. For early diagnosis and successful treatment, awareness and high suspicion of this rare type of early onset APT is crucial in patients with amiodarone therapy.

摘要

胺碘酮是一种广泛应用的抗心律失常药物。在其各种不良反应中,胺碘酮引起的肺毒性(APT)是最具威胁生命的并发症,这种情况大多发生在长期接受高累积剂量治疗的患者中。然而,短期胺碘酮治疗引起的 APT 很少有报道。我们描述了一例 54 岁男性患者,在心肌梗死后室性心动过速治疗几天后出现 APT 症状。为了早期诊断和成功治疗,对于接受胺碘酮治疗的患者,早期发病的这种罕见类型 APT 的早期诊断和高度怀疑至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1573/3831017/2b79c8147340/kcj-43-699-g001.jpg

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