某些多硫酸化多糖对人滑膜成纤维细胞透明质酸（HA）合成的影响。
The effects of some polysulphated polysaccharides on hyaluronate (HA) synthesis by human synovial fibroblasts.
作者信息
Smith M M, Ghosh P
出版信息
Agents Actions Suppl. 1986;18:55-62. doi: 10.1007/978-3-0348-7684-1_8.
The in vitro synthesis of HA in synovial fibroblasts derived from normal and rheumatoid joints was investigated. Incubation of these cells with ArteparonR and a variety of sulphated dextrans showed that macromolecular HA synthesis could be modified by these drugs. ArteparonR and a dextran sulphate (DS1) of molecular weight 20,600 and 0.8 sulphate substitution stimulated HA synthesis in rheumatoid cells by approximately 150%. In contrast the dextrans with higher sulphate substitution but similar molecular weight were less effective. Gel filtration chromatography of media from drug-treated cells showed an increase in HA hydrodynamic size.
研究了从正常关节和类风湿关节衍生的滑膜成纤维细胞中透明质酸（HA）的体外合成。将这些细胞与阿替帕隆（ArteparonR）和多种硫酸化葡聚糖一起孵育，结果表明这些药物可以改变大分子HA的合成。阿替帕隆和分子量为20,600且硫酸取代度为0.8的硫酸葡聚糖（DS1）使类风湿细胞中的HA合成增加了约150%。相比之下，具有较高硫酸取代度但分子量相似的葡聚糖效果较差。对药物处理细胞的培养基进行凝胶过滤色谱分析，结果显示HA流体力学尺寸增加。
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