Latorre Uriza Catalina, Roa Nelly S, Velosa-Porras Juliana, Villamil Poveda Jean Carlos, Otero Liliana, Ruiz Alvaro J, Escobar Arregoces Francina María
Centro de Investigaciones Odontológicas, Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Departamento de Medicina Interna, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Biomedicines. 2024 Jun 27;12(7):1425. doi: 10.3390/biomedicines12071425.
A positive relationship has been reported between advanced periodontitis and carotid intima-media thickness (cIMT) measurement. The aim of this study was to investigate this relationship with parameters for periodontitis, such as PISA and systemic inflammation biomarkers. An observational descriptive cross-sectional study was conducted. A blood sample was collected from 75 subjects to analyze glucose, total cholesterol, HDL, LDL, and cytokine values. Increased cIMT was found in 32% of the patients with fewer teeth. Patients with periodontitis had a larger periodontal inflamed surface area (PISA) ( = 0.000) and had a 1.42-times-higher risk of having increased cIMT values compared to periodontally healthy individuals, though without a statistically significant association. Higher values in the left cIMT, IL-8, and TNF-α were found in men than in women with significant differences. In the multivariate analysis involving cytokines, age continues to be linked to increased cIMT values. INF-γ showed a trend towards a protective effect; as the IMT-M decreases, there is an increase in the expression of INF-γ, and a higher proportion of subjects with elevated INF-γ concentrations demonstrated normal IMT-C. This study did not find a statistically significant association between cIMT and periodontal disease, but the risk of having increased cIMT is 1.42-times higher for individuals with periodontitis.
据报道，重度牙周炎与颈动脉内膜中层厚度（cIMT）测量值之间存在正相关关系。本研究的目的是通过牙周炎参数（如牙周炎累及面积（PISA））和全身炎症生物标志物来研究这种关系。开展了一项观察性描述性横断面研究。采集了75名受试者的血样，以分析血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白和细胞因子值。在牙齿较少的患者中，32%发现cIMT增加。与牙周健康个体相比，牙周炎患者的牙周炎累及面积（PISA）更大（P = 0.000），cIMT值增加的风险高1.42倍，不过无统计学显著关联。男性的左cIMT、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）值高于女性，差异有统计学意义。在涉及细胞因子的多变量分析中，年龄仍然与cIMT值增加有关。干扰素-γ（INF-γ）显示出一种保护作用趋势；随着内膜中层厚度均值（IMT-M）降低，INF-γ表达增加，INF-γ浓度升高的受试者中，内膜中层厚度上限值（IMT-C）正常的比例更高。本研究未发现cIMT与牙周病之间存在统计学显著关联，但牙周炎患者cIMT增加的风险高1.42倍。
