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抗结核治疗后出现耳部痛风石的痛风:一例报告

Gout with auricular tophi following anti-tuberculosis treatment: a case report.

作者信息

Chang Hsin-Jen, Wang Pa-Chun, Hsu Ying-Chieh, Huang Shih-Hung

机构信息

Department of Pathology, Cathay General Hospital, Taipei, Taiwan.

出版信息

BMC Res Notes. 2013 Nov 21;6:480. doi: 10.1186/1756-0500-6-480.

Abstract

BACKGROUND

Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites.

CASE PRESENTATION

We present a 64-year-old man who had multiple painless nodules over bilateral helix. An excisional biopsy was performed. Hematoxylin-eosin staining of biopsy specimens revealed a proteinaceous matrix that surrounded dissolved crystals, consistent with gout tophi. Bilateral auricular tophi are not common and may resemble a number of other diseases including squamous cell carcinomas, Kaposi's sarcoma, epidermal and dermoid cysts, rheumatoid nodules. Biopsy should be performed to rule out malignancy.

CONCLUSIONS

Tophi of the auricle are usually asymptomatic but can become inflamed and occasionally ulcerate through the overlying skin. Chronic tophaceous gout is treated with dietary control and medication. Surgical excision is performed under local anesthetic if symptoms progression or cosmetically deformity is concerned.

摘要

背景

耳廓痛风石是结晶形式的尿酸钠坚实沉积物,可在耳部皮下组织中缓慢形成。耳部并非痛风石常见的发病部位,但当这种病变确实发生时,耳轮和对耳轮是常见部位。

病例介绍

我们报告一名64岁男性,双侧耳轮有多个无痛性结节。进行了切除活检。活检标本苏木精-伊红染色显示有围绕溶解晶体的蛋白质基质,符合痛风石表现。双侧耳廓痛风石并不常见,可能类似多种其他疾病,包括鳞状细胞癌、卡波西肉瘤、表皮样囊肿和皮样囊肿、类风湿结节。应进行活检以排除恶性肿瘤。

结论

耳廓痛风石通常无症状,但可发生炎症,偶尔可穿透覆盖皮肤形成溃疡。慢性痛风石性痛风采用饮食控制和药物治疗。如果考虑到症状进展或美容畸形,则在局部麻醉下进行手术切除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf65/3843551/c2af650c4f45/1756-0500-6-480-1.jpg

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