先天性巨细胞病毒感染：临床结果。
Congenital cytomegalovirus infection: clinical outcome.
机构信息
Departments of Pediatrics.
出版信息
Clin Infect Dis. 2013 Dec;57 Suppl 4(Suppl 4):S178-81. doi: 10.1093/cid/cit629.
Abstract
Congenital cytomegalovirus (CMV) infection is a leading cause of hearing loss and neurologic disabilities in children worldwide. Infants with symptomatic congenital CMV infection at birth are at significantly increased risk for developing adverse long-term outcomes. The vast majority of infants with congenital CMV infection have no clinical findings at birth (asymptomatic infants), and about 10%-15% of these children develop long-term sequelae. Currently, predictors of adverse outcome in asymptomatic congenital CMV infection are not known, and it is important that future studies address this issue.
摘要
先天性巨细胞病毒（CMV）感染是全球导致儿童听力损失和神经发育障碍的主要原因。出生时患有有症状先天性 CMV 感染的婴儿发生不良长期结局的风险显著增加。绝大多数患有先天性 CMV 感染的婴儿在出生时没有临床发现（无症状婴儿），其中约 10%-15%的儿童会出现长期后遗症。目前，无症状先天性 CMV 感染不良结局的预测因素尚不清楚，未来的研究解决这个问题非常重要。
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2
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3
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4
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