为视网膜母细胞瘤基因定义新的愿景：第三届国际 Rb 会议报告。
Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting.
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Departments of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA.
出版信息
Cell Div. 2013 Nov 21;8(1):13. doi: 10.1186/1747-1028-8-13.
The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family of transcription factors. In response to mitogenic signals, Cyclin-dependent kinases (CDKs) phosphorylate Rb family members, which results in the disruption of complexes between Rb and E2F family members and in the transcription of genes essential for S phase progression. Beyond this role in early cell cycle decisions, Rb family members regulate DNA replication and mitosis, chromatin structure, metabolism, cellular differentiation, and cell death. While the RB pathway has been extensively studied in the past three decades, new investigations continue to provide novel insights into basic mechanisms of cancer development and, beyond cancer, help better understand fundamental cellular processes, from plants to mammals. This meeting report summarizes research presented at the recently held 3rd International Rb Meeting.
视网膜母细胞瘤肿瘤抑制因子 (Rb) 通路在大多数（如果不是全部）人类肿瘤中发生突变。在 G0/G1 期，Rb 及其家族成员 p107 和 p130 抑制 E2F 转录因子家族。响应有丝分裂信号，细胞周期蛋白依赖性激酶 (CDKs) 磷酸化 Rb 家族成员，导致 Rb 与 E2F 家族成员之间的复合物解离，以及 S 期进展所必需的基因转录。除了在早期细胞周期决策中的这一作用外，Rb 家族成员还调节 DNA 复制和有丝分裂、染色质结构、代谢、细胞分化和细胞死亡。虽然 RB 通路在过去三十年中得到了广泛研究，但新的研究继续为癌症发展的基本机制提供新的见解，并且超越癌症，有助于更好地理解从植物到哺乳动物的基本细胞过程。本会议报告总结了最近举行的第三届国际 Rb 会议上提交的研究报告。
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