Institute of Physiology, Bulgarian Academy of Sciences, bl. 23, Acad. G. Bonchev St., 1113, Sofia, Bulgaria.
Biol Trace Elem Res. 1985 Nov;8(3):211-8. doi: 10.1007/BF02917460.
The effects of copper deficiency on the fatty acid composition of mitochondrial and microsomal phospholipids in rat liver were studied. Copper deficiency was induced by a milk powder diet. To evaluate the effect of the milk diet on the fatty acid pattern of mitochondrial and microsomal phospholipids, one group of rats was fed Cusupplemented powdered milk. A decrease in the relative proportion of linoleic acid and an increase in the level of oleic and docosahexaenoic acids in membrane phospholipids were found in this group. However, no changes in the fatty acid pattern characteristic of essential fatty acid deficiency were observed. Dietary copper deficiency produced a significant decrease in the relative amounts of linoleic and arachidonic acids, as well as an increase in the docosahexaenoic acid content in both mitochondrial and microsomal membranes compared to the nondeficient controls. The disproportionate quantities of polyunsaturated fatty acids are discussed with a view to the disturbances of membrane function in copper deficiency.
研究了铜缺乏对大鼠肝线粒体和微粒体磷脂脂肪酸组成的影响。采用奶粉饮食诱导铜缺乏。为了评估牛奶饮食对线粒体和微粒体磷脂脂肪酸模式的影响，一组大鼠喂食添加铜的奶粉。结果发现，该组细胞膜磷脂中亚油酸的相对比例降低，油酸和二十二碳六烯酸的水平升高。然而，没有观察到必需脂肪酸缺乏特征的脂肪酸模式的变化。与非缺乏对照组相比，饮食铜缺乏导致线粒体和微粒体膜中亚油酸和花生四烯酸的相对含量显著减少，二十二碳六烯酸含量增加。讨论了多不饱和脂肪酸的不成比例数量，以期了解铜缺乏症对膜功能的干扰。
