Department of Surgery, East Carolina University School of Medicine, 27834, Greenville, North Carolina.
Biol Trace Elem Res. 1985 Dec;8(4):231-5. doi: 10.1007/BF02989578.
The administration of nembutal and chloral hydrate anesthetic agents in the rat produces an increase in the uptake of zinc, as Zn-65, in the liver. Associated with this is the appearance of a low-molecular-weight Zn-binding protein in the soluble cytosol fraction. This protein is comparable to that induced by the stress of severe exercise, by burn injury, and by Zn injection, and is probably Zn metallothionein. This is an example of the induction of a Zn binding protein in the liver by a drug, and confirms that anesthesia significantly effects Zn metabolism in the liver. Consequently this effect of anesthetic agents should be taken into account in the investigation of the regulation of Zn metabolism.
戊巴比妥和水合氯醛麻醉剂在大鼠中的给药导致肝脏中锌-65 的摄取增加。与此相关的是，在可溶性胞质溶胶部分出现了一种低分子量的锌结合蛋白。这种蛋白质与由剧烈运动、烧伤和锌注射引起的应激诱导的蛋白质相当，可能是锌金属硫蛋白。这是药物诱导肝脏中锌结合蛋白的一个例子，并证实麻醉剂显著影响肝脏中的锌代谢。因此，在研究锌代谢的调节时，应该考虑麻醉剂的这种作用。
